Gastrin, somatostatin, G and D cells of gastric ulcer in rats

doi:10.3748/wjg.v8.i2.375

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Apr 15, 2002 (publication date) through Aug 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 15, 2002; 8(2): 375-378
Published online Apr 15, 2002. doi: 10.3748/wjg.v8.i2.375

Table 1 Gastrin concentration in rat plasma, gastric juice, and antral mucosa (¯x ± s, n = 7)

Group	Plasma (ng·L^-1)	Gastric juice (ng·L^-1)	Ulcer mucosa (ng·g^-1)	Non-ulcer mucosa (ng·g^-1)
Control	147 ± 41	44 ± 15	-	3.7 ± 1.1
4 d	397 ± 130^a	56 ± 16	2.0 ± 0.7	6.7 ± 2.3^a
7 d	364 ± 91^a	114 ± 34^a	1.3 ± 0.4^b	6.1 ± 1.8^a
10 d	255 ± 87^a	60 ± 20	2.3 ± 0.8	1.9 ± 0.7^a
14 d	238 ± 88	45 ± 21	1.9 ± 0.7	1.1 ± 0.4^a
21 d	211 ± 65	44 ± 17	1.3 ± 0.4^b	1.1 ± 0.7^a
28 d	216 ± 95	60 ± 18	1.5 ± 0.5	1.5 ± 0.3^a

^aP < 0.05, vs control group.

^bP < 0.05, vs 4 d group.

Table 2 Somatostatin concentration in rat plasma, gastric juice, and antral mucosa (¯x ± s, n = 7)

Group	Plasma (ng·L^-1)	Gastric juice (ng·L^-1)	Ulcer mucosa (ng·g^-1)	Non-ulcer mucosa (ng·g^-1)
Control	45 ± 12	64 ± 16	-	1.4 ± 0.4
4 d	13 ± 5^a	46 ± 15^a	0.3 ± 0.1	0.4 ± 0.1^a
7 d	22 ± 8^a	42 ± 15^a	0.3 ± 0.1	0.4 ± 0.2^a
10 d	41 ± 9	54 ± 17	0.2 ± 0.1	0.8 ± 0.2^a
14 d	33 ± 8^a	54 ± 12	0.9 ± 0.4^b	1.3 ± 0.4
21 d	32 ± 9^a	49 ± 12	1.1 ± 0.2^b	1.1 ± 0.4
28 d	45 ± 12	64 ± 16	1.1 ± 0.3^b	1.1 ± 0.3

^aP < 0.05, vs control group.

^bP < 0.05, vs 4 d group.

Table 3 Number and area of G and D cells, and the ratio of G/D number and G/D area (¯x ± s, n = 7)

Group	No. (G cells)	Area of G cells(× 10^-6 m²)	No. (D cells)	Area of G cells (× 10^-6 m²)	Number ratioof G/D	Area ratio of G/D
Control	33 ± 6	99 ± 7	15 ± 2	70 ± 11	2.3 ± 0.1	1.4 ± 0.1
4 d	50 ± 7^a	87 ± 7^a	10 ± 2^a	56 ± 8^a	4.9 ± 0.3^a	1.6 ± 0.1^a
7 d	69 ± 8^a	91 ± 7^a	9 ± 2^a	60 ± 9^a	7.6 ± 0.5^a	1.5 ± 0.2
10 d	73 ± 13^a	94 ± 7	10 ± 1^a	63 ± 7	7.4 ± 0.4^a	1.5 ± 0.1
14 d	62 ± 11^a	95 ± 9	11 ± 2^a	66 ± 11	5.8 ± 0.5^a	1.5 ± 0.1
21 d	46 ± 8^a	95 ± 8	14 ± 2	68 ± 11	3.4 ± 0.2^a	1.4 ± 0.1
28 d	43 ± 6^a	95 ± 7	14 ± 2	66 ± 8	3.1 ± 0.1^a	1.4 ± 0.1

^aP < 0.05, vs control group.

Table 4 Relationship between rat G and D cells, and between G or D cells and gastrin or somatostatin

Group	No. of G cells vsNo. of D cells	Area of G cells vs area of D cells	No.of G cells vsgastrin in non-ulcer mucosa	No.of D cells vssomatostatin in non-ulcer mucosa	Area of G cellsvsgastrin in non-ulcer mucosa	Area of D cells vssomatostatin in non-ulcer mucosa
Control	0.97^b	0.95^b	0.95^b	0.93^b	0.94^b	0.93^b
4 d	0.92^b	0.93^b	0.87^a	0.90^b	0.98^b	0.86^a
7 d	0.97^b	0.93^b	0.98^b	0.98^b	0.93^b	0.94^b
10 d	0.97^b	0.96^b	0.93^a	0.88^b	0.93^b	0.95^b
14 d	0.91^b	0.99^b	0.87^a	0.89^b	0.78^a	0.99^b
21 d	0.97^b	0.88^b	0.90^b	0.68	0.98^b	0.99^b
28 d	0.99^b	0.94^b	0.95^b	0.89^b	0.92^b	0.96^b

^aP < 0.05,

^bP < 0.01, vs control group.

Citation: Sun FP, Song YG, Cheng W, Zhao T, Yao YL. Gastrin, somatostatin, G and D cells of gastric ulcer in rats. World J Gastroenterol 2002; 8(2): 375-378
URL: https://www.wjgnet.com/1007-9327/full/v8/i2/375.htm
DOI: https://dx.doi.org/10.3748/wjg.v8.i2.375