Influence of IFNα-2b and BCG on the release of TNF and IL-1 by Kupffer cells in rats with hepatoma

Table 1 The influence of biological immunal modulants on the release of TNF and IL-1 by KCs of normal rat in vivo

Groups	TNF (ng/L)	IL-1 (SI)
Control	56.2 ± 10.5	1.40
BCG	79.4 ± 17.6a	2.27b
IFNα-2b	134.9 ± 51.4b	1.84a
IFNα-2b + BCG	199.5 ± 71.5b	2.54b

n = 18,

^aP < 0.05,

^bP < 0.01 vs control.

Table 2 The influence of biological immunal modulants on the release of TNF and IL-1 by KCs of rats with hepatoma in vivo

Groups	2nd week		16th week
	TNF (ng/L)	IL-1 (SI)	TNF (ng/L)	IL-1 (SI)
Control	50.1 ± 9.4	1.57	79.4 ± 10.6	1.58
BCG	234.4 ± 63.1b	2.58b	148.5 ± 47.2a	2.74b
IFNα-2b	251.2 ± 82.1b	2.33b	166.0 ± 30.5a	2.42b
IFN-2b + BCG	281.8 ± 63.3b	2.80b	354.8 ± 96.4b	4.08b

n = 18,

^aP < 0.05,

^bP < 0.01 vs control.

Table 3 The influence of biological immune modulants on the release of TNF and IL-1 by KCs of rats with hepatoma in vitro

Groups	TNF (ng/L)	IL-1 (SI)
Control	100.0 ± 20.6	1.42
BCG	141.3 ± 31.7b	1.80a
IFNα-2b	199.5 ± 61.2b	1.64a
IFNα-2b + BCG	223.8 ± 42.4b	2.24b

n = 18,

^aP < 0.05,

^bP < 0.01 vs control.