Function of apoptosis and expression of the proteins Bcl-2, p53 and C-myc in the development of gastric cancer

Table 1 Relationship between apoptosis, protein expression of bcl-2, p53, C-myc and each kind of gastric diseases

	Chronic active gastritis	Gastric ulcer	Non-classic proliferation		Gastric cancer
			Mild	Severe	Early	Progressive
Sample numbers	32	29	17	8	6	30
Apoptosis index%	16.8 ± 12.3	24.1 ± 20.0a	19.3 ± 16.4	15.7 ± 15.2c	10.1 ± 9.1d	6.3 ± 6.0e
Bcl-2 positive	3	8	9	6	5	14
Numbers(%)	(9.4)	(27.6)a	(52.9)b	(75.0)c	(83.3)	(46.7)e
C-myc positive	5	6	6	4	3	20
Numbers(%)	(15.6)	(20.7)	(35.3)b	(50.0)	(50.0)	(63.3)e
p53 positive	0	0	0	2	2	19
Numbers(%)				(25.0)c	(33.3)	(63.3)e

*Compared with left itim:

^aP < 0.05, gastric ulcer vs chronic active gastritis;

^bP < 0.05, mild non-classic proliferation vs gastric ulcer;

^cP < 0.05, severe non-classic proliferation vs mild non-classic proliferation;

^dP < 0.05, early gastric cancer vs severe non-classic proliferation;

^eP < 0.05, early gastric cancer vs progressive gastric cancer.

Table 2 Relationship between apoptosis, protein expression of Bcl-2, p53, C-myc and Lauren typing of gastric cancer

Lauren typing	Sample numbers	Apoptosisindex%	Bcl-2 positivenumbers(%)	C-myc positivenumbers(%)	p53 positivenumbers(%)
Intestinal	18	8.3 ± 7.2	7 (38.9)	13 (77.7)	15 (83.3)
Diffuse	12	5.1 ± 4.9a	7 (58.3)a	6 (50.0)a	4 (33.3)b

^aP < 0.05, Diffuse vs Intestinal;

^bP < 0.01, Diffuse vs Intestinal.