Gastrin, somatostatin, and experimental disturbance of the gastrointestinal tract in rats

doi:10.3748/wjg.v7.i3.399

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Jun 15, 2001 (publication date) through Nov 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 15, 2001; 7(3): 399-402
Published online Jun 15, 2001. doi: 10.3748/wjg.v7.i3.399

Table 1 Gastrin in body fluids (n = 10, ^-x±s, ng/L)

Group	Plasma	Gastric juice	Intestinal juice
A	168.40 ± 38.01	48.72 ± 12.55	147.36 ± 31.47
B	109.46 ± 40.88^a	30.78 ± 6.81^a	96.58 ± 14.36^a
C	150.38 ± 31.75	51.17 ± 7.56^b	171.19 ± 25.28^b
D	119.48 ± 30.21^a	33.03 ± 6.64^a^c	122.57 ± 31.61^b^c
E	179.84 ± 64.77^b^d	54.29 ± 7.05^b^d	79.01 ± 33.31^a^b^d

^aP < 0.05 vs A,

^bP < 0.05 vs B,

^cP < 0.05 vs C,

^dP < 0.05 vs D.

Table 2 Somatostatin in body fluids (n = 10, ^-x±s, ng/L)

Group	Plasma	Gastric juice	Intestinal juice
A	17.93 ± 4.46	9.70 ± 2.14	13.43 ± 3.08
B	32.56 ± 7.91^a	29.21 ± 4.58^a	25.74 ± 4.16^a
C	18.24 ± 4.02^b	11.69 ± 2.53^b	15.30 ± 3.31^b
D	20.87 ± 4.68^b	22.56 ± 4.99^a^b^c	24.16 ± 4.50^a^c
E	16.98 ± 3.53^b	7.64 ± 2.26^b^c^d	13.85 ± 2.19^b^d

^aP < 0.05 vs A,

^bP < 0.05 vs B,

^cP < 0.05 vs C,

^dP < 0.05 vs D.

Table 3 Gastrin in tissues (n = 10, ^-x±s, ng/g)

Group	Gastric antrum	Jejunum	Hypothalamus
A	503.77 ± 74.32	38.57 ± 8.14	107.85 ± 16.36
B	232.61 ± 53.88^a	22.47 ± 3.02^a	68.09 ± 13.40^a
C	493.75 ± 91.20^b	35.76 ± 6.41^b	102.79 ± 12.29^b
D	372.31 ± 54.35^a^b^c	28.46 ± 5.48^a^b^c	89.95 ± 11.11^a^b^c
E	535.67 ± 57.58^b^d	41.31 ± 7.27^b^d	110.03 ± 12.94^b^d

^aP < 0.05 vs A,

^bP < 0.05 vs B,

^cP < 0.05 vs C,

^dP < 0.05 vs D.

Table 4 Somatostatin in tissues (n = 10, ^-x±s, ng/g)

Group	Gastric antrum	Jejunum	Hypothalamus
A	175.19 ± 26.24	23.50 ± 6.36	43.96 ± 6.45
B	367.15 ± 42.30^a	47.31 ± 10.97^a	66.76 ± 6.55^a
C	207.23 ± 34.08^b	21.00 ± 5.66^b	45.56 ± 5.57^b
D	327.94 ± 46.68^a^b^c	25.88 ± 7.57^b	59.45 ± 6.02^a^b^c
E	184.94 ± 57.58^b^d	17.61 ± 5.12^b	39.98 ± 5.40^b^d

^aP < 0.05 vs A,

^bP < 0.05 vs B,

^cP < 0.05 vs C,

^dP < 0.05 vs D.

Table 5 G cells and D cells of gastric antrum mucosa (n = 10, ^-x±s)

Group	G cells			D cells
Group	Number	Square (± 10^-6 m²)	Even grey	Number	Square (× 10^-6 m²)	Even grey
A	103.60 ± 12.33	98.05 ± 7.06	125.41 ± 2.29	15.67 ± 5.21	70.49 ± 8.96	124.04 ± 3.14
B	40.33 ± 5.53^a	93.47 ± 6.55	128.24 ± 3.03^a	5.70 ± 1.32^a	45.41 ± 5.27^a	115.38 ± 2.62^a
C	72.70 ± 10.14^a^b	94.31 ± 5.77	125.90 ± 3.13^b	11.20 ± 2.55^a^b	61.05 ± 7.11^a^b	123.72 ± 3.10^b
D	50.63 ± 7.54^a^b^c	87.54 ± 8.92^a^b^c	123.15 ± 4.09^a^b^c	8.30 ± 1.86^a^b^c	43.54 ± 5.06^a^c	123.27 ± 2.26^b
E	88.03 ± 10.37^a^b^c^d	97.16 ± 6.24^d	125.39 ± 2.22^b^d	13.83 ± 3.11^a^b^c^d	72.71 ± 5.88^b^c^d	124.47 ± 2.46^b

^aP < 0.05 vs A,

^bP < 0.05 vs B,

^cP < 0.05 vs C,

^dP < 0.05 vs D.

Table 6 G cells and D cells of jejunum mucosa (n = 10, ^-x±s)

Group	G cells			D cells
Group	Number	Square (× 10^-6 m²)	Even grey	Number	Square (× 10^-6 m²)	Even grey
A	63.57 ± 10.16	81.99 ± 9.75	125.44 ± 3.14	7.80 ± 2.58	60.56 ± 7.26	125.82 ± 1.70
B	29.43 ± 7.11^a	78.49 ± 6.94	130.24 ± 2.01^a	3.13 ± 1.14^a	41.80 ± 5.14^a	111.29 ± 3.26^a
C	54.83 ± 10.03^a^b	73.63 ± 6.55^a^b	124.58 ± 2.31^b	6.77 ± 1.98^b	53.92 ± 6.86^a^b	125.94 ± 2.58^b
D	35.37 ± 9.16^a^b^c	62.18 ± 6.07^a^b^c	122.34 ± 2.56^a^b^c	5.10 ± 1.92^a^b^c	44.52 ± 6.02^a^c	123.80 ± 2.96^b
E	65.10 ± 9.63^b^c^d	77.44 ± 7.69^a^d	125.80 ± 2.45^b^d	7.53 ± 2.26^b^d	61.77 ± 10.27^b^c^d	125.47 ± 2.76^a^b^c^d

^aP < 0.05 vs A,

^bP < 0.05 vs B,

^cP < 0.05 vs C,

^dP < 0.05 vs D.

Table 7 Ratio of the number and square on G/D cells (n = 10, ^-x±s)

Group	Gastric antrum		Jejunum
Group	Number (cells)	Square	Number (cells)	Square
A	6.48 ± 0.77	1.42 ± 0.24	8.43 ± 1.57	1.39 ± 0.20
B	7.20 ± 0.54^a	2.05 ± 0.37^a	9.82 ± 2.71^a	1.87 ± 0.30^a
C	6.47 ± 0.69	1.55 ± 0.26^b	8.25 ± 1.46^b	1.38 ± 0.21^b
D	5.95 ± 1.13^b	2.01 ± 0.30^a^c	7.33 ± 1.16^b	1.18 ± 0.25^b^c
E	6.81 ± 0.61^d	1.29 ± 0.13^a^b^c^d	8.53 ± 1.87^b	1.24 ± 0.25^b

^aP < 0.05 vs A,

^bP < 0.05 vs B,

^cP < 0.05 vs C,

^dP < 0.05 vs D.

Citation: Yao YL, Xu B, Zhang WD, Song YG. Gastrin, somatostatin, and experimental disturbance of the gastrointestinal tract in rats. World J Gastroenterol 2001; 7(3): 399-402
URL: https://www.wjgnet.com/1007-9327/full/v7/i3/399.htm
DOI: https://dx.doi.org/10.3748/wjg.v7.i3.399