Carcinogenic potential of duodenal reflux juice from patients with long-standing postgastrectomy

Table 1 Operation types and critical toxicity of reflux juice in each histological grade

Histological grades	Billroth I	Billroth II	Critical toxic concentrations (%, v:v)	Correlation between histological grades and toxicitya
1 Chronic superficial gastritis	7	10	16.4 ± 4.0
2 Atrophic gastritis/intestinal metaplasia	4	7	15.8 ± 5.0
3 Dysplasia	2	7	12.9 ± 4.6	rs = -0.287，P = 0.085

^aTwo tailed spearman's rank correlation.

Table 2 Histological grades of stoma and carcinogenic potential of reflux juice in the cell transformation assay

Histological grades	TF (%)		Correlation coefficienta
	Initiating	Promoting	Initiating	Promoting
1 Chronic superficial gastritis	20.1 ± 18.4 (8)	25.3 ± 18.7 (9)
2 Atrophic gastritis/intestinal metaplasia	26.0 ± 20.7 (5)	48.1 ± 20.1 (6)	rs = 0.161	rs = 0.625
3 Dysplasia	20.4 ± 7.10 (5)	56.7 ± 10.6 (4)	P = 0.523	P = 0.004

^aTwo tailed Spearman's rank correlation. The number of the patients for each histological grade is inside the parentheses.