Inhibitory effects of EGFR antisense oligodeox-ynucleotide in human colorectal cancer cell line

Table 1 Inhibitory effects of liposome-ODN

Group	48 h		72 h
	MTT value (x-± s)	Inhibition rate (%)	MTT value (x-± s)	Inhibition rate (%)
Control	0.445 ± 0.016		0.337 ± 0.003
Liposome-RC15	0.389 ± 0.015	12.6	0.091 ± 0.008	12.2
Liposome-AEGFR	0.078 ± 0.022	82.5	0.079 ± 0.005	76.6

Table 2 Cell cycle assay

Group	G0/G2 (%)	S (%)	G2 + M (%)	PI
Control	21.6	59.9	18.5	0.784
Liposome-RC15	29.5	54.9	15.6	0.705
Liposome-AEGFR	57.1	32.5	10.1	0.329

Table 3 Inhibition of subcutaneous HR8348 adenocarcinoma growth by ASODN

Group	Diameter of tumor (cm)	Rate of tumorigenicity (%)
Control	1.00 ± 0.08	100 (10/10)
Liposome-RC15	0.95 ± 0.07	100 (10/10)
Liposome-AEGFR	0.80	20 (2/10)