Study on arsenic trioxide inducing in vitro apoptosis of gastric cancer cell lines

Table 1 Cytocide effects of As₂O₃ (5 μmol) on various cell categories (%,^-x±s)

Group	MKN45	7901	K562	PBL
24 h	69.45 ± 11.12	68.27 ± 8.27	51.36 ± 10.25a	30.31 ± 5.12b
48 h	71.40 ± 10.15	69.04 ± 11.31	57.11 ± 7.45a	35.67 ± 4.37b
72 h	80.53 ± 10.18	82.74 ± 9.14	65.33 ± 8.24a	39.74 ± 8.27b

Comparison of cytocide rate between GCCL and controls by As₂O₃,

^aP < 0.05 (t > 2.2262),

^bP < 0.01 (t > 3.250)

Table 2 Apoptosis rate (%) of MKN45 by different treatment methods (^-x±s)

Group	Controls	5-Fu	As2O3 1	As2O3 2
24 h	4.71 ± 0.36	18.04 ± 1.50	32.33 ± 3.75a	60.02 ± 7.41b
48 h	14.90 ± 0.94	24.39 ± 3.45	90.59 ± 10.35b	97.05 ± 8.24b
72 h	28.98 ± 3.12	41.47 ± 2.24	98.10 ± 13.24b	98.75 ± 11.53b

Comparison of apoptosis rate between As₂O₃ and 5-Fu group,

^aP < 0.05 (t > 2.2262),

^bP < 0.01 (t > 3.250).

Table 3 Apoptosis rate (%) of SGC7901 by different treatment methods (^-x±s)

Group	Controls	5-Fu	As2O3 1	As2O3 2
48 h	7.44 ± 0.60	34.28 ± 4.15	51.33 ± 5.16a	78.31 ± 9.14b
72 h	30.90 ± 2.54	56.32 ± 4.56	78.15 ± 6.78a	89.28 ± 10.26b

Comparison of apoptosis rate between As₂O₃ and 5-Fu group,

^aP < 0.05 (t > 2.2262),

^bP < 0.01 (t > 3.250)