Treatment of Helicobactor pylori infection: analysis of Chinese clinical trials

Table 1 PPI dual therapy

Authors	Ome	Amo	Eradication (%)	Healing (%)	Side effect
Zhou YH[1]	20 bid × 14	500 qid × 14	30/33 (91)	31/33 (94)	12%
Zhou YH[1]	20 qd × 14	500 qid × 14	31/35 (89)	32/35 (91)
Nie YQ[2]	20 bid × 14	500 qid × 14	10/13 (77)	12/13 (92)	15%
Li YY[3]	20 bid × 14	500 qid × 14	8/11 (73)	9/11 (82)
Hu FL[4]	20 bid × 14	750 bid × 14	13/22 (59)	18/22 (82)
Zhou Y[5]	20 bid × 14	750 qid × 14	30/36 (83)	36/36 (100)	2.7%

Ome: Omeprazole Amo: Amoxycilline

Table 2 Furazolidone dual therapy

Authors	Furazolidone	Antibiotics	Eradication (%)	Side effect
Xiao SD[6]	100 qid × 14	CBS 120 qid × 14	66/90 (73)
Mao PJ[7]	100 tid × 28	Ran 150 bid × 28	10/17 (59)	8.9%
Mao PJ[7]	100 tid × 28	Ome 20 qd × 28	15/18 (83)
Li YN[8]	200 tid × 7	CBS 110 qid × 28	34/34 (100)
	100 qid × 7
Li YN[8]	100 tid × 14	CBS 110 qid × 28	21/23 (91)
Li YN[8]	50 tid × 14	CBS 110 qid × 28	13/21 (62)
Xi BG[9]	200 tid × 14	CBS 110 qid × 28	24/24 (100)

CBS: Bismuth Ran: Ranitidine Ome: Omeprazole

Table 3 Triple therapy with Furazolidone

Authors	Fu	Antibiotics	Antibiotics	Eradication (%)	Side effect
Liu WZ[10]	200 bid × 7	CBS 240 bid × 7	Cla 500 bid × 7	12/12 (100)	57%
Liu WZ[10]	100 bid × 7	CBS 240 bid × 7	Cla 250 bid × 7	25/27 (93)	7.4%
Huang YS[11]	100 tid × 5	Met 400 tid × 5	Genta 40 tid × 5	25/26 (96)
Xiao SD[6]	100 qid × 10	CBS 120 qid × 10	Met 200 qid × 10	74/75 (78)
Chen JP[12]	100 qid × 28	CBS 120 qid × 28	Tetra 250 qid × 28	35/54 (65)

Cla: Clarithromycin Genta: Gentamycin Tetra: Tetracyclin

Table 4 Hp eradication with CBS triple therapy

Authors	CBS	Amo	Met	Eradication (%)	Side effect
Jia BQ[13]	120 qid × 14	250 qid × 14	200 qid × 14	328/440 (87)	7.8%
Jia BQ[13]	240 bid × 14	500 bid × 14	400 bid × 14	139/156 (89)	7.8%
Chen SP[14]	240 bid × 14	1000 bid × 14	400 bid × 14	33/46 (71)
Li QN[15]	240 bid × 14	500 bid × 14	400 bid × 14	13/16 (81)	37.5%
Geng Z[16]	110 qid × 14	500 qid × 14	200 qid × 14	64/76 (84)
Zhou LY[17]	120 qid × 14	250 qid × 14	200 qid × 14	56/73 (77)
Li YY[18]	120 qid × 14	250 qid × 14	200 qid × 14	20/25 (80)	28%

Table 5 PPI triple therapy

Authors	PPI	Antibiotics	Cla	Eradication (%)	Side effect
Chen SP[14]	Ome 20 bid × 7	Amo 1000 bid × 7	500 bid × 7	43/48 (90)	21.1%
Chen SP[14]	Ome 20 bid × 14	Amo 1000 bid × 14	500 bid × 14	45/47 (96)
Liu WZ[10]	Lan 30 bid × 7	Fu 200 bid × 7	500 bid × 7	11/12 (92)	10%
Liu WZ[10]	Lan 30 qd × 7	Fu 100 bid × 7	250 bid × 7	27/30 (90)
Li QN[15]	Lan 30 bid × 7	Met 400 bid × 7	250 bid × 7	14/16 (86)	18.8%
Li QN[15]	Lan 30 bid × 7	Met 400 bid × 7	500 bid × 7	15/16 (94)	25%