Effect of gastrin on protein kinase C and its subtype in human colon cancer cell line SW480

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Apr 15, 2000 (publication date) through Dec 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 15, 2000; 6(2): 304-306
Published online Apr 15, 2000. doi: 10.3748/wjg.v6.i2.304

Table 1 Effect of gastrin on protein kinase C activation (mean ± SD)

	Protein kinase C (pmol•min•mg protein)
	Cytosol	Membrane
Control	2.39 ± 1.30	1.07 ± 0.28
Gastrin (25 mg/L)	0.91 ± 0.34^a	2.65 ± 1.21^a
Gastrin (25 mg/L) + proglumide (32 mg/L)	2.30 ± 0.61	1.05 ± 0.20

Note:

^aP ＜ 0.05 vs control (n = 5).

Table 2 Time-dependent effect of gastrin on protein kinase C activation

	Protein kinase C (pmol•min•mg protein)
	Cytosol	Membrane
Control	2.39 ± 1.30	1.07 ± 0.28
PG (25 mg/L)
1 min	0.91 ± 0.34^a	2.65 ± 1.21^a
2 min	1.44 ± 0.34	1.87 ± 0.57^a
5 min	2.28 ± 0.49	0.98 ± 0.18

Note:

^aP ＜ 0.05 vs control (n = 5).

Citation: Xie B, He SW, Wang XD. Effect of gastrin on protein kinase C and its subtype in human colon cancer cell line SW480. World J Gastroenterol 2000; 6(2): 304-306
URL: https://www.wjgnet.com/1007-9327/full/v6/i2/304.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.i2.304