Effects of endotoxin on endothelin receptor in hepatic and intestinal tissues after endotoxemia in rats

Table 1 Effects of endotoxin on ETR of hepatic and intestinal tissue

	Control	Endotoxin-treated group
		3rd	6th	12th	24th (h)
Liver
Bmax (bB/pmol•mg¯¹p)	0.9969 ± 0.0155	0.7476 ± 0.0356b	0.5590 ± 0.0219b	0.4258 ± 0.0156b	0.5826 ± 0.0586b
Kd (CB/nmol•L¯¹)	0.0328 ± 0.0018	0.0338 ± 0.0016	0.0332 ± 0.0014	0.0324 ± 0.0010	0.0333 ± 0.0017
Intestine
Bmax (bB/pmol•mg¯¹p)	1.2950 ± 0.2070		0.8810 ± 0.1026a	0.6340 ± 0.2109b	0.5199 ± 0.2260b
Kd (CB/nmol•L¯¹)	0.1309 ± 0.0183	0.1344 ± 0.0140	0.1181 ± 0.0173	0.1281 ± 0.0173	0.1260 ± 0.0169

^aP ＜ 0.05,

^bP ＜ 0.01 vs control group.

Table 2 Effect of endotoxin on relative quantity of hepatic and inte stinal ET-A receptor nRNA (μg DNA/g RNA)

	Control	Endotoxin-treated group
		3rd	6th	12th	24th (h)
Liver	17.13 ± 2.11	57.96 ± 11.51b	86.35 ± 16.01b	95.50 ± 13.24b	27.93 ± 3.05b
Intestine	38.43 ± 3.86	48.32 ± 4.31b	69.42 ± 8.21b	68.61 ± 10.24b	42.41 ± 3.73

^bP ＜ 0.01 vs control group.