Inhibitory effects of Curcuma aromatica oil on proliferation of hepatoma in mice

Table 1 Inhibitory effects of CAO on growth of hepatoma in mice

Experiment	Drugs	Dose (kg¯¹·d¯¹)	Number	Body weight change (g)	Tumor weight (g)	Tumor inhibitory rate (%)
1	Ns	0.2 mL	7	6.90	1.08 ± 0.22
	5-FU	40 mg	7	-2.00	0.35 ± 0.13	67.6b
	CAO	100 mg	7	4.35	0.52 ± 0.16	51.8b
2	Ns	0.2 mL	10	5.55	1.72 ± 0.45
	5-FU	20 mg	10	-1.85	0.45 ± 0.15	73.8b
	CAO	100 mg	10	4.60	0.84 ± 0.31	51.2b

Results are expressed as mean ± SD, n = 10,

^bP ＜ 0.01, vs negative control group.

Table 2 Effects of CAO on the hepatoma DNA parameters detected with ICM in mice

Group	DO	NA (μm2)	DI	5CER (%)	2C (%)	3-5C (%)
Negative control	430 ± 160	1073 ± 101	4.48 ± 0.71	70.9 ± 14.9	2.97 ± 5.69	28.2 ± 16.0
CAO	249 ± 70b	623 ± 228a	2.38 ± 0.67b	30.0 ± 15.1b	29.00 ± 9.34b	41.0 ± 17.4

Results are expressed as mean ± SD, n = 10,

^aP ＜ 0.05,

^bP ＜ 0.01, vs negative control group.

Table 3 Effects of CAO on the expressions of hepatoma PCNA in mice

Group	PCNA-LI (%)
Negative control	40.0 ± 5.7
Positive control	25.1 ± 3.6 b
CAO	29.9 ± 3.9 b

Results are expressed as mean ± SD, n = 10,

^bP ＜ 0.01, vs negative control group.