VIP immunoreactive nerves and somatostatin and serotonin containing cells in Crohn’s disease

Table 1 Lv and Vv of immunoreactive nerve fibers and neurons for V IP, S-100 protein and NSE in Crohn’s disease

Item	CD		Control		P
	n	-x±s	n	-x±s
VIP
Mucosa Lv	25	3.6 ± 1.2	10	2.0 ± 0.8	< 0.01
Submucosa Vv	25	2.0 ± 1.1	10	0.9 ± 0.8	< 0.01
Submucosal neuron (diameter, μm)	25	21.1 ± 5.6	10	13.1 ± 2.0	< 0.01
Myenteric plexus Vv	25	3.2 ± 1.8	10	2.6 ± 1.4	< 0.01
NSE
Mucosa Lv	25	3.4 ± 0.7	10	1.9 ± 1.4	< 0.01
Submucosa Vv	25	5.1 ± 2.2	10	1.3 ± 0.5	< 0.01
Myenteric plexus Vv	25	11.1 ± 2.6	10	5.1 ± 1.2	< 0.01
S-100 protein
Submucosa Vv	25	3.9 ± 1.0	10	2.3 ± 0.4	< 0.01
Myenteric plexus Vv	25	9.4 ± 2.3	10	5.7 ± 1.0	< 0.01

Table 2 Density of serotonin, SS containing cells and argyrophil cells in Crohn’s disease

Group	Serotonin containing cell		SS containing cell		Argyrophil cell
	n	-x±s	n	-x±s	n	-x±s
CD	25	4.2 ± 1.7b	25	1.0 ± 0.6b	25	3.2 ± 1.5b
Control	10	8.9 ± 2.9	10	2.0 ± 1.2	10	7.7 ± 2.5

^bP < 0.01, vs normal control.