Expression of c-src gene in the carcinogenesis process of human cardia adenocarcinoma

Table 1 The expression of PP60^c-src in CA and related lesions

Lesion	Case	Staining intensity			Positive rate (%)
		-(%)	+(%)	+ + - + + +(%)
Normal epithelia	34	24(70.5)	10(29.4)	0(0)	10(29.4)
Proliferative epithelia	36	2(5.6)	6(16.7)	28(77.8)d	34(94.4)b
Cardia adenocarcinoma	56	16(28.6)	20(35.7)	20(35.7)d	40(71.4)b
Lymph node metastases	20	8(40.0)	8(40.0)	4(20.0)	12(60.0)

^bP < 0.01, in comparison of the positive rates in different lesions ( χ² = 34.19) vs normal epithelia;

^dP < 0.01, in comparison of the positive intensity in different lesions ( χ² = 25.08) vs normal epithelia.

Table 2 The expression of PP60^c-src in CA of different histo logical types

Lesion	Case	Staining intensity			Positive rate (%)
		-(%)	+(%)	+ + - + + +(%)
Papillary	8	2(25.0)	6(75.0)	0(0)	6(75.0)
Tubular	22	4(18.2)	4(18.2)	14(63.6)b	18(81.8)a
Poorly differentiated	20	10(50.0)	10(50.0)	0(0)	10(50.0)
Mucous	6	0(0)	0(0)	6(100.0)b	6(100.0)a
Total	56	16(28.6)	20(35.7)	20(35.7)	40(71.4)

^aP < 0.05,in comparison of the positive rat es of tubular and mucous adenocarcinomas vs those of papillary and poorly differentiated adenocarcinomas ( χ² = 8.11);

^bP < 0.01,in comparison of the positive rates of tubular and mucous adenocarcinomas vs those of papillary and poorly differentiated adenocarcinomas ( χ² = 27.56).