Copyright
©The Author(s) 1999.
World J Gastroenterol. Jun 15, 1999; 5(3): 209-212
Published online Jun 15, 1999. doi: 10.3748/wjg.v5.i3.209
Published online Jun 15, 1999. doi: 10.3748/wjg.v5.i3.209
Table 1 Serum ALT activities of Balb/c mice in different time (IU/L, 1IU/L = 16.67 nmol·s-1/L)
t/h | NS | CSA | SEB | D-GalN | SEB + D-GalN | CSA + SEB + D-GalN |
2 | 51.8 ± 16.4 | 51.5 ± 17.8 | 59.5 ± 18.8 | 71.3 ± 25.7a | 69.0 ± 24.6a | 54.2 ± 24.5 |
6 | 56.0 ± 21.3 | 63.0 ± 18.1 | 60.5 ± 20.3 | 81.3 ± 24.7a | 95.7 ± 38.7b | 60.7 ± 29.4 |
12 | 54.8 ± 14.9 | 55.5 ± 27.5 | 56.5 ± 16.9 | 63.8 ± 22.8 | 4109.2 ± 1910.1b | 60.5 ± 26.7 |
24 | 59.7 ± 24.5 | 59.0 ± 24.7 | 59.5 ± 24.7 | 60.7 ± 26.3 | 65.7 ± 24.2 |
Table 2 Lethality within 24 h
D-GalN (mg/mice) | SEB (μg/mice) | CSA (mg/mice) | 24 h lethality (death/total) |
10 | 0/3 | ||
50 | 0/6 | ||
100 | 0/3 | ||
150 | 0/3 | ||
16 | 0/6 | ||
16 | 10 | 0/3 | |
16 | 50 | 3/6 | |
16 | 100 | 2/3 | |
16 | 150 | 3/3 | |
16 | 50 | 0.5 | 0/6 |
0.5 | 0/6 | ||
0/6a |
- Citation: Yin T, Tong SQ, Xie YC, Lu DY. Cyclosporin A protects Balb/c mice from liver damage induced by superan tigen SEB and D-GalN. World J Gastroenterol 1999; 5(3): 209-212
- URL: https://www.wjgnet.com/1007-9327/full/v5/i3/209.htm
- DOI: https://dx.doi.org/10.3748/wjg.v5.i3.209