Clinical and experimental study of effect of Raondix Salviae Militiorrhiza and other blood-activating and stasis-eliminating Chinese herbs on hemodynamics of portal hypertension

doi:10.3748/wjg.v4.i5.439

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Oct 15, 1998 (publication date) through Feb 4, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Combined Traditional And Modera Medicine

World J Gastroenterol. Oct 15, 1998; 4(5): 439-442
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.i5.439

Table 1 Effect of RSM, RAS and nifedipinc on hemodynamics in dogs with liver cirrhosis(KPa)

	RSM treatment group		RAS treatment group
	Before	After 60 min	Before	After 60 min
Ppv	2.56 ± 0.30	1.82 ± 0.33^b	2.42 ± 0.05	1.38 ± 0.32^b
FHVP	1.39 ± 0.47	1.10 ± 0.28	0.98 ± 0.15	0.94 ± 0.06
WHVP	2.17 ± 0.36	1.70 ± 0.30^b	2.33 ± 0.09	1.90 ± 0.33^a
HVPG	0.93 ± 0.33	0.60 ± 0.43^b	1.35 ± 0.16	0.97 ± 0.30^a
ICVP	1.02 ± 0.34	0.99 ± 0.29	1.05 ± 0.35	1.02 ± 0.32
MAP	13.75 ± 2.40	13.30 ± 2.34	14.07 ± 3.18	13.13 ± 2.48
HR(beat/min)	134.00 ± 1.72	147.80 ± 22.36	138.75 ± 28.39	137.00 ± 28.02

^aP < 0.05,

^bP < 0.01 vs compared with petreatment.

Table 2 Comparesion among the effect of RSM, RAS on Dpv HVPG

	RSM vs RSA		RSM vs nifedipine		RSM vs nifedipine
	Ppv	HVPG	Ppv	HVPG	Ppv	HVPG
Treatment
30 min	1.29	1.96	3.06	2.30	4.13^a	4.26^a
60 min	2.51		3.57^a		5.95^a

^aP < 0.05, vs compared in any two group.

Table 3 The effect of RSM, RAS and other drugs on portal hemodyamics in patients with liver cirrhosis

Group	Dpv (mm)		Dsv (m)		Qpv (mL/min)		Qsv (mL/min)
Group	Before	1 0 weeks	Before	10 weeks	Before	10 weeks	Before	10 weeks
1	14.84 ± 1.03	13.06 ± 1.58^c	12.20 ± 1.92	10.03 ± 1.93^c	2346.95 ± 1592.29	1686.93 ± 1056.05^b	2065.50 ± 1209.17	1421.38 ± 924.99^b
2	14.80 ± 0.92	14.37 ± 0.09^b	11.10 ± 1.67	10.38 ± 0.186^b	1673.42 ± 203.19	1564.49 ± 267.08	1717.60 ± 919.34	1099.04 ± 744.82^a
3	15.03 ± 1.29	13.62 ± 0.09^c	11.78 ± 3.16	10.97 ± 0.28^b	2117.47 ± 676.31	1753.40 ± 593.46^a	1825.89 ± 1151.13	1312.28 ± 780.56^b
4	14.75 ± 1.39	13.05 ± 0.65^b	11.58 ± 2.31	9.87 ± 2.05^a	1794.74 ± 641.06	1226.08 ± 321.16^a	1781.92 ± 1197.19	1087.74 ± 70.45^a

Group 1: RSM; group 2: RAS; group 3: RSM nifedipine; group 4:RSM+bloodsucker+ nifedipine, compared in any two group

^aP < 0.05

^bP < 0.01

^cP < 0.01.

Table 4 Comparesion of the used drugs on Dpv

	Group 1-2	Group 1-3	Group 1-4	Group 2-3	Group 2-4	Group 3-4
Administration
2 weeks	-0.254	-4.220^c	-2.637^a	-3.633^c	-2.265^a	0.881
6 weeks	3.042^b	-0.153	-2.635	-2.917^b	-2.941^b	-0.415
10 weeks	4.563^c	1.217	-0.098	-3.055^b	-3.628^c	-0.982

Group 1: RSM; group 2: RAS; group 3: RSM + nifedipine; group 4:RSM+leach+ nifedipine, compared in any two group.

^aP < 0.05

^bP < 0.01

^cP < 0.01.

Citation: Yao XX, Cui DL, Sun YF, Li XT. Clinical and experimental study of effect of Raondix Salviae Militiorrhiza and other blood-activating and stasis-eliminating Chinese herbs on hemodynamics of portal hypertension. World J Gastroenterol 1998; 4(5): 439-442
URL: https://www.wjgnet.com/1007-9327/full/v4/i5/439.htm
DOI: https://dx.doi.org/10.3748/wjg.v4.i5.439