Basaloid squamous carcinoma of esophagus: a clinicopathological, immunohistochemical and electron microscopic study of sixteen cases

Table 1 Clinicopathological, Staging, Therapeutic and Follow-up Data in 16 Patients with Esophageal BSC

Case No	Age/sex	Tumor location	Tumor size (cm)	Gross appearance	Stage	Therapy		Mitoses (per 10HPF)	Follow-up
						Surgery	Chemo-therapy
1	42/F	Lower 1/3	2.5 × 1.5 × 0.6	Polypoid	IIA(T2N0M0)	Curative esophagectomy		198	Not available
2	56/M	Middle 1/3	2.5 × 2.0 × 0.8	Protuberant	IIA(T3N0M0)	Curative esophagectomy		51	Not available
3	50/F	Lower 1/3	4.0 × 2.0 × 1.0	Ulcerative	III(T3N1M0)	Curative esophagectomy		74	Not available
4	62/M	Middle 1/3	3.5 × 1.5	Protuberant	IIA(T2N0M0)	Curative esophagectomy	+	86	Died of tumorrecurrence at 18mo
5	56/M	Lower 1/3	4.3 × 2.8 × 1.8	Protuberant	I(T1N0M0)	Curative esophagectomy	+	60	Alive & well at 10a
6	62/M	Upper 1/3	2.8 × 1.0 × 0.7	Ulcerative	III(T3N1M0)	Curative esophagectomy	+	45	Died of tumor, recurrence 14mo after operation
7	54/M	Middle 1/3	4.0 × 2.8	Infiltrative	IV(T2N0M1)	Palliative esophagectomy	+	47	Metastases to lung and pleura, died 12mos after operation
8	60/F	Middle 1/3	2.5 (in diameter	Infiltrative	III(T3N1M0)	Curative esophagectomy	+	98	Died of metastases and recurrence 8mo later
9	72/M	Middle 1/3	5.5 × 2.0	Ulcerative	IIA(T3N0M0)	Curative esophagectomy		136	Not available
10	62/F	Middle 1/3	3.5 × 2.0 × 3.0	Protuberant	IIA(T2N0M0)	Curative esophagectomy		49	Not available
11	49/M	Middle 1/3	3.5 × 3.0	Ulcerative	IV(T4N1M1)	Paliative esophagectomy	+	54	Metastases to lung and brain, Died 9mo after operation
12	70/M	Lower 1/3	5.0 × 2.0 × 1.5	Infiltrative	III(T3N1M0)	Curative esophagectomy	+	82	Died of tumor， recurrence 4a after operation
13	67/M	Middle 1/3	5.0 × 4.8 × 2.0	Infiltrative	IIA(T3N0M0)	Curative esophagectomy	+	104	Died 16mo after operation
14	57/F	Middle 1/3 (with two lesions)	2.0 × 1.5 1.3(in diameter )	Ulcerative	IIB(T1N1M0)	Curative esophagectomy	+	60	Died 3mo after diagnosis
15	57/F	Middle 1/3	7.0 × 5.0 × 3.0	Protuberant	III(T4N1M0)	Palliative esophagectomy	+	85	Died 8mo after operation
16	52/F	Middle 1/3	4.0 × 2.5	Protuberant	IIB(T2N1M0)	Curative esophagectomy	+	105	Alive 4mo after operation

The criteria of the UICC TNM classification system (1987) was used.

Table 2 Histochemical and immunohistochemical findings

Case	Component	CK	EMA	CEA	Vim	S-100	SMA	Stroma
								ABP	AS	D-PAS
1	B	+	+	-	-	-	-	+	+	+
	S	++	++	-	-	-	-
	SP	-	-	++	-	-
2	B	+++	+	-	+	-	-	-	+	+
	S	+++	+++	-	-	-	-
3	B	++	+	-	-	-	-	+	+	+
	S	+++	+	-	-	-	-
4	B	++	+	-	-	-	-	-	+	+
	S	+++	+++	-	-	-	-
5	B	+	+	-	-	-	-	+	+	+
	S	+	+++	+	-	-	-
6	B	+++	+	-	++	-	-	-	+	+
	S	+++	+++	+	-	-	-
7	B	+++	-	-	-	++	-	+	+	+
	S	+++	+++	-	-	-	-
	SP	-	-	-	++	-	+
8	B	++	+	-	-	-	-	+	+	+
	S	++	++	-	-	-	-
9	B	+++	++	-	-	+	-	-	+	+
	S	+++	++	-	-	-	-
10	B	+	+	-	-	+	-	-	+	+
	S	++	+++	-	-	-	-
11	B	-	++	-	-	-	-	-	+	+
	S	+++	++	-	-	-	-
12	B	++	++	-	-	+	-	+	+	+
	S	+++	++	-	-	-	-
13	B	-	+	-	-	+	-	-	+	+
	S	++	++	-	-	-	-
14	B	+++	++	-	-	-	-	+	+	+
	S	+++	++	-	-	-	-
	SM	++	++	-	-	-	-
15	B	++	+	-	+++	+++	-	+	+	+
	S	+++	+++	++	-	-	-
16	B	+	+	-	++	+	-	-	+	+
	S	+++	++	-	-	-	-

B: basaloid cell; S: squamous cell; SP: spindle cell; SM: small cell; D-PAS: diastase treating PSA stain