Nutritional status in non-alcoholic subclinical porto-systemic encephalopathy

doi:10.3748/wjg.v4.i5.380

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Oct 15, 1998 (publication date) through Dec 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 15, 1998; 4(5): 380-384
Published online Oct 15, 1998. doi: 10.3748/wjg.v4.i5.380

Table 1 Vital and laboratory data of cirrhotic patients with and without SPSE

	Controls ( ) (n = 20)	SPSE
	Controls ( ) (n = 20)	(-) (n = 27)	(+) (n = 24)
Age (yrs)	53 ± 13	57 ± 9	59 ± 12
Sex (M/F)	14/6	16/11	18/6
Total bilirubin (mg/L)	8.5 ± 5.1	22.2 ± 18.8^a	64.9 ± 106.0^b^c
Albumin (g/L)	39 ± 7	31 ± 7^a	28 ± 5^b^c
ALT (IU/L)	19 ± 9	60 ± 76^a	89 ± 100^a
Prolonged prothrombin time (s)	0.9 ± 0.5	1.9 ± 1.5^a	2.8 ± 1.9^b^c
Indocyanine green clearance (%)	4 ± 3	27 ± 19^b	35 ± 17^b^c
Ammonia (μmol/ L)	15.7 ± 7.14	29.3 ± 15.7	32.8 ± 14.3
Child Pugh (A/B/C)		17/6/4	8/11/5^b
N20-N65 inter peak latencies (ms)	40.2 ± 3.0	45.9 ± 8.5	50.2 ± 9.6^b^d

^aP < 0.01, compared with control subjects;

^bP < 0.001, compared with control subjects;

^cP < 0.05, compared with cirrhotic patients without SPSE, and

^dP < 0.001, compared with cirrhotic patients without SPSE.

Table 2 Vital and laboratory data of cirrhotic patients in Child-Pugh classes A, B and C

	Child-Pugh
	A (n = 25)	B (n = 17)	C (n = 9)
Age (yrs)	59 ± 9	61 ± 6	50 ± 11
Sex (M/F)	16/9	11/6	7/2
Total bilirubin (μmol/L)	15.4 ± 6.8	27.4 ± 12.9^a	148.8 ± 109.4^a^b
Albumin (g/dL)	34 ± 5	26 ± 3^a	24 ± 2^a
ALT (IU/L)	58 ± 56	103 ± 59	102 ± 83
Prolonged prothrombin time (s)	1.5 ± 0.9	2.3 ± 1.1^a	4.6 ± 1.5^a^b
Ammonia (μmol/L)	27.8 ± 10.0	29.3 ±14.3	34.4 ± 7.9
Indocyanine green clearance (%)	20 ± 17	35 ± 12^c	45 ± 9^a
N20-N65 inter peak latencies (ms)	45.9 ± 8.5	50.2 ± 7.4	48.0 ± 3.7

^aP < 0.001, compared with Child-Pugh class A;

^bP < 0.001, compared with Child-Pugh class B;

^cP < 0.05, compared with Child-Pugh class A.

Table 3 Leukocyte subsets (/μL) of cirrhotic patients with and without SPSE

	Controls	SPSE
	Controls	(-)	(+)
Leukocytes	7088 ± 1557	4507 ± 1546^a	4686 ± 1380^a
Polymorphonuclear nutrophils	4658 ± 1668	2398 ± 1089^a	2714 ± 1904^a
Lymphocytes	1842 ± 747	1250 ± 644^a	1485 ± 603^a
Monocytes	376 ± 120	305 ± 137	307 ± 167
Eosinophils	204 ± 231	99 ± 70^a	116 ± 88^a
Basophils	41 ± 28	30 ± 15	24 ± 24
CD3+ leukocytes	1231 ± 557	586 ± 325^a	618 ± 420^a
CD4+/CD8+	1.5 ± 0.8	1.9 ± 0.9^a	1.9 ± 0.9^a
IL-2R+ leukocytes	94 ± 61	63 ± 58	104 ± 106
HLA-DR+ leukocytes	30 ± 20	76 ± 129^a	66 ± 59^a
CD14+ leukocytes	368 ± 149	366 ± 469	350 ± 310
CD19+ leukocytes	218 ± 134	199 ± 114	169 ± 113

^aP < 0.05, compared with control subjects.

Table 4 Leukocyte subsets (/ μL) of cirrhotic patients with Child-Pugh calss A, B and C

	Child-Pugh
	A	B	C
Leukocytes	4152 ± 1237	3951 ± 1097	5669 ± 1299
Polymorphonuclear neutrophils	2306 ± 758	2231 ± 674	3824 ± 1037
Lymphocytes	1418 ± 595	1371 ± 567	1180 ± 422
Monocytes	280 ± 130	245 ± 92	442 ± 182
Eosinophils	113 ± 84	95 ± 57	114 ± 59
Basophils	31 ± 22	29 ± 12	38 ± 14
CD3+ leukocytes	569 ± 300	619 ± 316	655 ± 316
CD4+/CD8+	2.0 ± 1.0	2.0 ± 0.7	1.7 ± 0.6
IL-2R+ leukocytes	77 ± 83	45 ± 29	112 ± 68
HLA-DR+ leukocytes	59 ± 68	124 ± 115	48 ± 27
CD14+ leukocytes	326 ± 379	327 ± 185	510 ± 310
CD19+ leukocytes	178 ± 107	187 ± 91	200 ± 107

Table 5 Nutritional profiles of cirrhotic patients with and without SPSE

	Controls	SPSE
	Controls	(-)	(+)
Albumin (m/L)	39 ± 4	31 ± 7^a	28 ± 5^b^c
Prealbumin (mg/L)	313 ± 57	125 ± 58^d	106 ± 57^d
Transferrin (mg/dL)	215 ± 50	178 ± 58^a	164 ± 46^d
BMI (kg/m²)	24.2 ± 3.5	25.3 ± 3.6	23.7 ± 2.7
MAMC (cm)	22.1 ± 3.6	22.7 ± 3.5	22.2 ± 2.6
Grip power (kg)	28.8 ± 10.6	26.9 ± 6.8	26.3 ± 6.4

BMI: body mass index, MAMC: mid arm muscle circumference.

^aP < 0.05, compared with control subjects;

^bP < 0.005, compared with control subjects;

^cP < 0.001, compared with cirrhotic patients without SPSE;

^dP < 0.001, compared with control subjects.

Table 6 Nutritional profiles of cirrhotic patients in Child-Pugh classes A, B and C

	Child-Pugh
	A	B	C
Albumin (m/L)	34 ± 5	26 ± 3^a	24 ± 2^a
Prealbumin (mg/L)	152 ± 52	93 ± 31^a	60 ± 19^a^b
Transferrin (mg/dL)	1.96 ± 35	1.54 ± 39^c	1.35 ± 38^c
BMI (kg/m ²)	24.3 ± 2.6	24.9 ± 2.5	22.9 ± 2.1
MAMC (cm)	22.3 ± 2.7	22.2 ± 2.4	22.9 ± 2.1
Grip power (kg)	30.0 ± 8.5	27.9 ± 6.8	22.5 ± 6.4

BMI: body mass index, MAMC: mid arm muscle circumference.

^aP < 0.001, compared with Child-Pugh class A;

^bP < 0.001, compared with Child Pugh class B;

^cP < 0.005, compared with Child-Pugh class A.

Citation: Yang SS, Wu CH, Chen LL, Mo SC, Chen DF. Nutritional status in non-alcoholic subclinical porto-systemic encephalopathy. World J Gastroenterol 1998; 4(5): 380-384
URL: https://www.wjgnet.com/1007-9327/full/v4/i5/380.htm
DOI: https://dx.doi.org/10.3748/wjg.v4.i5.380