Effects of octreotide on gallbladder pressure and myoelectric activity of Oddi sphincter in rabbits

Table 1 Effect of OT and SS on gallbladder pressure

Groups	n	Changes in gallbladder pressure (basic pressure = 0 kPa)
		2	10	20	40	60	80	100	120 min
NS	5	-0.024	-0.000	-0.013	-0.013	-0.010	-0.010	-0.012	-0.020
		± 0.020	± 0.024	± 0.024	± 0.032	± 0.024	± 0.024	± 0.024	± 0.040
OT	6	-0.074a	-0.097b	-0.068	-0.135	-0.101	-0.120	-0.068	-0.052
(5 μg/kg)		± 0.012	± 0.023	± 0.024	± 0.050	± 0.062	± 0.052	± 0.038	± 0.031
OT2	19	-0.142bc	-0.196bd	-0.184a	-0.154a	-0.257a	-0.145	-0.104	-0.040
(10 μg/kg)		± 0.020	± 0.052	± 0.034	± 0.052	± 0.065	± 0.048	± 0.036	± 0.042
SS	7	-0.143b	-0.122a	-0.071	-0.021	0.029
(10 μg/kg)		± 0.034	± 0.037	± 0.021	± 0.036	± 0.028

^aP < 0.05,

^bP < 0.01 vs NS group;

^cP < 0.05,

^dP < 0.01, vs group 1 OT.

Table 2 Effect of OT and SS on frequency of myoelectric activity of SO

Groups	n	Changes in frequency of myoelectric activity of SO (%)
		2	10	20	40	60	80	100	120 min
NS	5	-8.0	-4.0	-2.0	0.0	4.0	-3.0	-1.0	-2.0
		± 8.2	± 6.5	± 5.0	± 11.0	± 6.0	± 6.0	± 8.2	± 5.0
OT1	6	-51.4b	-42.3a	-18.5	-5.0	-4.0	5.0	-2.0	4.0
(5 μg/kg)		± 6.1	± 11.9	± 9.0	± 10.0	± 6.0	± 6.5	± 4.5	± 5.3
OT2	19	-83.1bd	-65.0a	-21.5	5.0	3.5	-4.0	-4.0	-3.5
(10 μg/kg)		± 8.0	± 11.3	± 9.3	± 6.2	± 9.1	± 7.0	± 5.0	± 8.5
SS	7	-86.7b	-78.5a	-48.9	-10.0	7.0
(10 μg/kg)		± 11.0	± 14.0	± 14.0	± 18.8	± 9.0

^aP < 0.05,

^bP < 0.01 vs NS group; ^cP < 0.05,

^dP < 0.01, vs OT 1 group.

Table 3 Comparision of effects of iv CCK-8 and electric stimulation of DMV on gallbladder pressure and myoelectric activity of SO after

Group	n	Changes of frequency of myoelectric activity of SO (%)		Changes in gallbladder pressure (basic pressure = 0 kPa)
		Before	After	Before	After
DMV OT	10	283.8 ± 69.6	285.8 ± 75.8	0.128 ± 0.046	0.123 ± 0.031
CCK-8 (100 ng) OT	12	346.8 ± 79.2	275.8 ± 37.7	0.363 ± 0.113	0.321 ± 0.112
CCK-8 (200 ng) SS	4	485.8 ± 78.9	426.4 ± 59.0	1.795 ± 0.468	1.955 ± 0.340

Before, before injection of TO or SS; After, after injection of OT or SS.