Reactive oxygen species and oxidative stress in acute pancreatitis: Pathogenesis and new therapeutic interventions

Table 1 Studies about the treatment of inhibitors or vitamins on acute pancreatitis

Ref.	Treatment	Journal	Year	Model
Gao et al[74]	NLRP3 and caspase-1 inhibitors	British Journal of Pharmacology Vol	2021	Caerulein-induced AP in mice
Rong et al[38]	Xanthine oxidase	Acta Pharmaceutica Sinica. B	2024	L-arginine-induced AP, caerulein-induced AP, and retrograde injection of 3.5% NaT induced AP in mice
Zheng et al[75]	Allopurinol	Pancreas	2008	Post-ERCP pancreatitis in patients
Romagnuolo et al[76]	Allopurinol	Clinical Gastroenterology and Hepatology	2008	Post-ERCP pancreatitis in patients
Katsinelos et al[77]	Allopurinol	Gastrointestinal Endoscopy	2005	Post-ERCP pancreatitis in patients
Li et al[78]	Deoxyarbutin	Free Radical Research	2022	Retrograde injection of 3.5% NaT induced AP in mice
Cuzzocrea et al[79]	iNOS inhibitors	Shock	2002	Caerulein-induced AP in mice
He et al[80]	Sulfiredoxin-1	Cell Death & Disease	2021	Caerulein-induced AP in mice
Zhao et al[81]	Melatonin	European Journal of Pharmacology	2024	Caerulein plus LPS induced AP in mice
Yuan et al[82]	Vitamin B12	Oxidative Medicine and Cellular Longevity	2021	Retrograde injection of 3.5% NaT induced AP in mice
Gui et al[83]	Vitamin C	Journal of Inflammation Research	2023	Retrograde injection of 3.5% NaT induced AP in mice
Sadeghi et al[84]	Vitamin C	Clinical Endoscopy	2023	Post-ERCP pancreatitis in patients

AP: Acute pancreatitis; ERCP: Endoscopic retrograde cholangiopancreatography; iNOS: Inducible nitric oxide synthase; LPS: Lipopolysaccharide; NaT: Sodium taurocholate; NLRP3: Nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3.

Table 2 Studies about treatment with traditional Chinese medicine or nanomaterials for acute pancreatitis

Ref.	Treatment	Journal	Year	Animal model
Yang et al[85]	Triptolide	International Journal of Molecular Sciences	2022	Caerulein-induced AP in mice
Ren et al[86]	Danshensu	Frontiers In Immunology	2018	Caerulein-induced AP in mice
Rong et al[87]	Resveratrol	Oxidative Medicine and Cellular Longevity	2021	Retrograde injection of 3.5% NaT induced AP in rats
Yang et al[88]	Chaiqin Chengqi Decoction	Frontiers In Pharmacology	2022	Obesity-related AP in mice
Xia et al[89]	Emodin	Inflammation	2019	Retrograde injection of 3.5% NaT induced AP in rats
Seo et al[90]	Quercetin 3-O-xyloside	Phytomedicine	2019	Lipopolysaccharide and cerulein-induced cellular AP
Xie et al[91]	Prussian blue nanozyme	Theranostics	2021	Caerulein-induced AP in mice
Zhou et al[92]	Celastrol	Molecular Pharmaceutics	2019	Retrograde injection of 3.5% NaT induced AP in rats

AP: Acute pancreatitis; NaT: Sodium taurocholate.