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World J Gastroenterol. Dec 7, 2024; 30(45): 4771-4780
Published online Dec 7, 2024. doi: 10.3748/wjg.v30.i45.4771
Reactive oxygen species and oxidative stress in acute pancreatitis: Pathogenesis and new therapeutic interventions
Chuan-Chao Xia, Hong-Tan Chen, Hao Deng, Yi-Ting Huang, Guo-Qiang Xu
Chuan-Chao Xia, Hong-Tan Chen, Hao Deng, Yi-Ting Huang, Guo-Qiang Xu, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Xia CC wrote the manuscript; Chen HT edited the manuscript; Huang YT and Deng H contributed to searching the literature; Xu GQ revised the manuscript.
Supported by the National Natural Science Foundation of China, No. 8217030254.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Qiang Xu, MD, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. 1193065@zju.edu.cn
Received: September 1, 2024
Revised: September 27, 2024
Accepted: October 29, 2024
Published online: December 7, 2024
Processing time: 72 Days and 19.6 Hours
Core Tip

Core Tip: Acute pancreatitis (AP) is a common acute gastrointestinal disorder. Reactive oxygen species significantly impact the progression and development of AP, and modulation of the oxidative stress pathway can effectively mitigate this condition. This systematic review examines the pivotal role of oxidative stress in the pathogenesis and progression of AP and the therapeutic potential of anti-oxidative stress interventions in its management.