Bibliometric study of sepsis-associated liver injury from 2000 to 2023

Table 1 Top 10 institutions in ranking of centrality

Rank	Centrality	Institution
1	0.06	Huazhong University of Science and Technology
2	0.06	Capital Medical University
3	0.04	Southern Medical University
4	0.04	Saarland University
5	0.04	University of Jena
6	0.03	Shanghai Jiao Tong University
7	0.03	Second Military Medical University
8	0.03	Chinese Academy of Medical Sciences
9	0.03	University of Pittsburgh
10	0.03	Mackay Memorial Hospital

Table 2 The top 10 most active journals and the top 10 co-citation journals

Rank	Journal	Publications	JCR (2022)	IF (2022)	Rank	Journal	Citations	JCR (2022)	IF (2022)
1	Shock	44	Q3	3.1	1	Critical Care Medicine	1093	Q1	8.8
2	Journal of Surgical Research	23	Q2	2.2	2	Shock	978	Q3	3.1
3	International Immunopharmacology	21	Q2	5.6	3	Hepatology	898	Q1	14
4	Frontiers in Pharmacology	17	Q1	5.6	4	Journal of Immunology	885	Q2	4.4
5	Frontiers in Immunology	15	Q1	7.3	5	Journal of Biological Chemistry	539	Q2	4.8
6	Critical Care Medicine	14	Q1	8.8	6	Journal of Hepatology	446	Q1	25.7
7	Experimental and Therapeutic medicine	11	Q3	2.7	7	Proceedings of The National Academy of Sciences of The United States of America	422	Q1	11.1
8	American Journal of Physiology- Gastrointestinal and Liver Physiology	10	Q2	4.5	8	Journal of Clinical Investigation	415	Q1	15.9
9	Biomedicine & Pharmacotherapy	10	Q1	7.5	9	Nature	409	Q1	64.8
10	Journal of Hepatology	10	Q1	25.7	10	Critical Care	406	Q1	15.1

JCR: Journal Citation Reports; Q1: Quarter 1; IF: Impact factor.

Table 3 The top 10 cited publications

Rank	Title	Cited Frequency	First Author	Journal	Year	Type
1	Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage	1014	Akio Ohta	Nature	2001	Article
2	The hepatic microcirculation: Mechanistic contributions and therapeutic targets in liver injury and repair	334	Brigitte Vollmar	Physiological Reviews	2009	Review
3	The role of the liver in sepsis	301	Jun Yan	International reviews of Immunology	2014	Review
4	L-Glycine: A novel antiinflammatory, immunomodulatory, and cytoprotective agent	268	Zhi Zhong	Current Opinion in Clinical Nutrition and Metabolic Care	2003	Review
5	The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis	246	David J van Westerloo	Journal of Infectious Diseases	2005	Article
6	Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K/AKT and NF-κB related signaling	183	Wen-Hui Zhong	Biomedicine & Pharmacotherapy	2016	Article
7	Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice	182	Evie H Carchman	Hepatology	2011	Article
8	Clinical review: The liver in sepsis	179	Nicolas Nesseler	Critical Care	2012	Review
9	Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver	159	Judit K Sarady	Faseb Journal	2004	Article
10	Problotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis	149	Julia Ewaschuk	Hepatology	2007	Article

Table 4 The top 10 co-cited references

Rank	Title	Times cited	Total link strength	First author	Journal	Year	Type
1	The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)	117	571	Mervyn Singer	JAMA	2016	Article
2	The role of the liver in sepsis	109	562	Jun Yan	International reviews of Immunology	2014	Review
3	Liver - guardian, modifier and target of sepsis	65	317	Pavel Strnad	Nature Reviews Gastroenterology & Hepatology	2017	Review
4	Immunodesign of experimental sepsis by cecal ligation and puncture	63	316	Daniel Rittirsch	Nature Protocols	2009	Article
5	Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care	63	263	D C Angus	Critical Care Medicine	2001	Article
6	Clinical review: The liver in sepsis	52	249	Nicolas Nesseler	Critical Care	2012	Review
7	Hepatic response to sepsis: Interaction between coagulation and inflammatory processes	50	209	J F Dhainaut	Critical Care Medicine	2001	Article
8	The epidemiology of sepsis in the United States from 1979 through 2000	48	231	Greg S Martin	New England Journal of Medicine	2003	Article
9	Incidence and prognosis of early hepatic dysfunction in critically ill patients-a prospective multicenter study	46	278	Ludwig Kramer	Critical Care Medicine	2007	Article
10	The pathophysiology and treatment of sepsis	41	147	Richard S Hotchkiss	New England Journal of Medicine	2003	Review

Table 5 The top 10 publications in impact index based on reference citation analysis

Rank	Title	Impact index	First author	Journal	Year	Type
1	Gut-liver crosstalk in sepsis-induced liver injury	19.5	Jian Sun	Critical Care	2020	Review
2	Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice	18.2	Shen-Hai Gong	Hepatology	2019	Article
3	CD39 Limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury	15.3	Luiz Eduardo Baggio Savio	Journal of hepatology	2017	Article
4	Herbal formula Baweibaidusan alleviates polymicrobial sepsis-induced liver injury via increasing the gut microbiota Lactobacillus johnsonii and regulating macrophage anti-inflammatory activity in mice	15	Xiao-Qing Fan	Acta Pharmaceutica Sinica B	2023	Article
5	The gut-liver axis in sepsis: Interaction mechanisms and therapeutic potential	15	Xue Zhang	Critical Care	2022	Review
6	6-Gingerol ameliorates sepsis-induced liver injury through the Nrf2 pathway	11	Mu-Keng Hong	International Immunopharmacology	2020	Article
7	YAP1 protects against septic liver injury via ferroptosis resistance	10	Jin Wang	Cell and Bioscience	2022	Article
8	Obeticholic acid protects mice against lipopolysaccharide-induced liver injury and inflammation	9.7	Xi Xiong	Biomedicine & Pharmacotherapy	2017	Article
9	PPARγ alleviates sepsis-induced liver injury by inhibiting hepatocyte pyroptosis via inhibition of the ROS/TXNIP/NLRP3 signaling pathway	8.5	Ze-Yu Li	Oxidative Medicine and Cellular Longevity	2022	Article
10	Novel role of resveratrol: Suppression of high-mobility group protein box 1 nucleocytoplasmic translocation by the upregulation of sirtuin 1 in sepsis-induced liver injury	7.9	Wei Xu	Shock	2014	Article

Table 6 The top 10 authors with the most publications and the top 10 authors by total link strength

Rank	Author	Country	Count	Total cites	Average cites	Rank	Author	Country	Citations	Total link strength
1	Christoph Thiemermann	United Kingdom	14	444	31.7	1	Brigitte Vollmar	Germany	58	1600
2	Asada Leelahavanichkul	Thailand	9	358	39.7	2	Hartmut Jaeschke	United States of America	97	1459
3	Henrik Thorlacius	Sweden	9	267	29.7	3	Richard S Hotchkiss	United States of America	157	1081
4	Brigitte Vollmar	Germany	8	460	57.5	4	Ping Wang	United States of America	86	908
5	Yu-Cai Zhang	China	8	140	17.5	5	Mervyn Singer	United Kingdom	133	897
6	Ping Wang	United States of America	8	325	40.6	6	Derek C Angus	United States of America	112	827
7	Ming-Yie Liu	China	7	189	27.0	7	W Wayne Lautt	Canada	23	796
8	Yun Cui	China	7	118	16.9	8	Jun Yan	China	110	701
9	Dur-Zong Hsu	China	7	189	27.0	9	Benedikt Pannen	Germany	19	566
10	Irshad H Chaudry	United States of America	6	288	48.0	10	Michael Bauer	Germany	34	562

Table 7 The top 20 most cited keywords

Rank	Keywords	Counts
1	Sepsis	335
2	Liver injury	327
3	Gene expression	164
4	TNF-α	144
5	Inflammation	140
6	Rat	123
7	Activation	118
8	Oxidative stress	115
9	NF-κB	94
10	Nitric oxide	92
11	CLP	86
12	Kupffer cell	83
13	Cell	79
14	Inhibition	67
15	Apoptosis	61
16	Mechanism	61
17	Dysfunction	57
18	LPS	57
19	Mortality	53
20	Liver	38

TNF-α: Tumor necrosis factor alpha; NF-κB: Nuclear factor-kappa B; CLP: Cecal ligation and puncture; LPS: Lipopolysaccharides.