Inhibition of hepatitis B virus via selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet

doi:10.3748/wjg.v30.i13.1911

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Apr 7, 2024 (publication date) through May 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2024; 30(13): 1911-1925
Published online Apr 7, 2024. doi: 10.3748/wjg.v30.i13.1911

Table 1 Differentially expressed genes in Liuweiwuling Tablet anti-hepatitis B virus effects identified through transcriptomic analysis and validated by real-time reverse transcriptase-PCR

Gene	Fold change	P value	Is it related with apoptosis
E2F1	4.44770094	0.008685393	No
PCNA	4.047933076	0.002898892	No
CASP8	3.570355797	0.003000082	Yes
TP53	3.452487306	0.016679865	Yes
CREBBP	2.885252648	0.003455666	No
IKBKE	2.849255028	0.016173753	No
PIK3R3	2.815615387	0.011672063	Yes
CCNE2	2.506258474	0.014722413	No
BCL2	2.239207884	0.007566661	Yes
AKT3	2.023770673	0.003487678	Yes
CREB3L2	0.621889559	0.006920633	No
EGR2	0.44857779	0.001957335	No
FOS	0.183742709	0.02708347	Yes

Citation: Ge FL, Yang Y, Si LL, Li YH, Cao MZ, Wang J, Bai ZF, Ren ZG, Xiao XH, Liu Y. Inhibition of hepatitis B virus via selective apoptosis modulation by Chinese patent medicine Liuweiwuling Tablet. World J Gastroenterol 2024; 30(13): 1911-1925
URL: https://www.wjgnet.com/1007-9327/full/v30/i13/1911.htm
DOI: https://dx.doi.org/10.3748/wjg.v30.i13.1911