Effects of Radix Rehmanniae on gastric acid secretion and gastric ulcer formation in rats

Table 1 Effects of dry Radix Rehmanniae (dRR) on gastric juice secretion (x- ± s)

Groups	n	Volume (mL)	Total acidity (µmol/mL)	Total acid output (µmol)
Control	10	2.9 ± 1.9	86.3 ± 16.1	241.3 ± 124.6
100% dRR	10	0.5 ± 0.6a	41.9 ± 29.1a	32.4 ± 56.6a
50% dRR	9	1.4 ± 0.9a	61.3 ± 33.6	104.3 ± 100.2a
F value		15.319	6.772	11.226

The data were tested with analysis of variance, q test was used in multiple comparison.

^aP < 0.05, as compared with control.

Table 2 Effects of steamed Radix Rehmannia (sRR) on gastric juice secretion (x- ± s)

Groups	n	Incidence	Number of ulcer	Inhibitory rate
Control	10	90%	10.2 ± 12.3	—
100% dRR	12	33%	3.1 ± 7.6a	69.60%
100% sRR	11	36%	1.1 ± 2.2a	89.20%
		χ2 = 8.27	F = 5.5112

The data were analyzed with k-ws test. “0” means no acid (pH > 7),

^aP < 0.05, compared with control.

Table 3 Effects of 100% dRR and 100% sRR on gastric ulcer formation in pylorus ligated rats (x- ± s)

Groups	n	Volume (mL)	Total acidity (µmol/mL)	Total acid output (µmol)
Control	10	2.9 ± 1.9	86.3 ± 16.1	241.3 ± 124.6
100% sRR	6	< 0.1a	0a	0a
50% sRR	10	0.9 ± 0.6a	73.3 ± 29.1	72.5 ± 53.4a

The means were tested with analysis of variance, q test was used in multiple comparison. The rate was analysed with χ² test for contingency table data.

^aP < 0.05, compared with control.