Effects of metoclopramide on gastrointestinal myoelectric activity in rats

Table 1 Effects of metoclopramide on myoelectric activity in the antrum of rats (x- ± s)

	Slow wave		Spike activity
	Frequency (num/min)	Amplitude (V)	Amplitude (V)
Control	4.6 ± 0.3	191.2 ± 143.9	121.8 ± 63.3
2.3 mg/kg	4.5 ± 0.3	192.4 ± 140.1	128.8 ± 54.9
6 mg/kg	4.6 ± 0.3	332.8 ± 200.1b	180.5 ± 69.7a
12 mg/kg	4.5 ± 0.2	330.0 ± 197.1b	174.5 ± 71.7a

Values represent mean ± SD (n = 8);

^aP < 0.05,

^bP < 0.01 vs control.

Table 2 Effects of metoclopramide on myoelectric activity in the small intestine of rats (x- ± s)

Sit	Groups	Slow wave		Spike activity
		Frequency (num/min)	Amplitude (V)	Amplitude (V)	Spike bursts(%)
1 cm	Control	38.2 ± 1.4	172.0 ± 101.9	345.0 ± 163.4	47.4 ± 22.5
	2.5 mg/kg	28.2 ± 1.6	175.0 ± 81.9	402.0 ± 138.4a	60.4 ± 22.0b
	6 mg/kg	38.0 ± 1.3	173.7 ± 110.1	407.3 ± 179.0a	61.7 ± 26.5b
	12 mg/kg	37.6 ± 1.1	179.0 ± 116.4	456.0 ± 145.4b	59.1 ± 17.3b
10 cm	Control	37.3 ± 1.4	201.2 ± 110.1	335.8 ± 138.6	38.1 ± 12.9
	2.5 mg/kg	36.9 ± 1.6	201.7 ± 113.3	383.6 ± 150.5	55.4 ± 16.1b
	6 mg/kg	37.0 ± 1.2	210.7 ± 105.2	412.5 ± 158.8b	54.3 ± 25.1b
	12 mg/kg	37.2 ± 1.3	202.5 ± 103.8	452.6 ± 144.3b	58.8 ± 15.6b
20 cm	Control	35.9 ± 1.1	153.2 ± 94.7	322.0 ± 93.1	37.9 ± 14.5
	2.5 mg/kg	36.6 ± 1.2	149.1 ± 69.1	338.2 ± 162.7	46.3 ± 12.1a
	6 mg/kg	36.2 ± 1.2	150.2 ± 50.2	356.4 ± 117.9	60.8 ± 22.6e
	12 mg/kg	35.6 ± 1.4	152.9 ± 73.4	347.3 ± 159.6	59.7 ± 24.2b

Values represent mean ± SD (n = 28);

^aP < 0.05,

^bP < 0.01,

^eP < 0.001 vs control.