P21 and CEA expression and AgNOR counts in dimethylhydrazine-induced colon carcinoma in rats

Table 1 DMH (dimethylhydrazine)-induced carcinogenesis in rats

Lesions	n	Incidence (%)	Number of mass
Well-differentiated adenocarcinoma	17	44.74	20
Undifferentiated adenocarcinoma	3	7.89	5
Mucinous adenocarcinoma	7	18.42	9
No tumor	11
Total	38	71.05	34

Table 2 Histological changes in colons of DMH (dimethylhydrazine)-treated rats

Histological types	T group	C group
Normal epithelial cell	0	61
Inflammation	10	4
Dysplasia	10	0
Adenoma	3	0
Carcinoma	34	0

¹With normal mucosa for all intestines.

Table 3 The distribution of positive P21 and Carcino Embryonie Antigen (CEA) immunohistochemical staining in rat colonic lesions

Histological types	n	p21 (%)	CEA (%)
Benign
Normal epithelial cell	10	0 (0.0)	0 (0.0)
Adenoma	3	1 (33.3)	0 (0.0)
Dysplasia	10	6 (60.0)	3 (30.0)
Malignant
Well-differentiated adenocarcinoma	20	14 (70.0)	16 (80.0)
Undifferentiated adenocarcinoma	5	1 (20.0)	4 (80.0)
Mucinous adenocarcinoma	9	7 (77.8)	6 (66.7)

P < 0.05 for p21 and CEA between benign and malignant lessions.