Copyright
©The Author(s) 2023.
World J Gastroenterol. Jun 21, 2023; 29(23): 3645-3657
Published online Jun 21, 2023. doi: 10.3748/wjg.v29.i23.3645
Published online Jun 21, 2023. doi: 10.3748/wjg.v29.i23.3645
Characteristic | Low expression of NPAS2 | High expression of NPAS2 | P value |
Number | 35 | 66 | |
Age, n (%) | 0.599 | ||
< 60 | 21 (60.0) | 36 (54.5) | |
≥ 60 | 14 (40.0) | 30 (45.5) | |
Sex, n (%) | 0.626 | ||
Female | 7 (20.0) | 16 (24.2) | |
Male | 28 (80.0) | 51 (75.8) | |
TNM stage, n (%) | 0.001 | ||
I-II | 25 (71.4) | 11 (16.7) | |
III-IV | 10 (28.6) | 55 (83.3) | |
pT stage, n (%) | 0.351 | ||
T1-T2 | 6 (17.1) | 29 (82.9) | |
T3-T4 | 7 (10.6) | 59 (89.4) | |
pN stage, n (%) | 0.009 | ||
N0 | 16 (45.7) | 12 (18.2) | |
N1-N3 | 19 (54.3) | 54 (81.8) | |
Metastasis, n (%) | 0.032 | ||
M0 | 35 (100.0) | 58 (87.9) | |
M1 | 0 (0.0) | 8 (12.1) | |
Tumor size, n (%) | 0.626 | ||
< 5 | 15 (42.9) | 25 (37.9) | |
≥ 5 | 20 (57.1) | 41 (62.1) | |
Tumor location, n (%) | 0.611 | ||
Antrum | 14 (40.0) | 33 (50.0) | |
Body | 9 (25.7) | 13 (19.7) | |
Cardia | 12 (34.3) | 20 (30.3) | |
Venous invasion, n (%) | 0.012 | ||
Negative | 9 (25.7) | 5 (7.6) | |
Positive | 26 (74.3) | 61 (92.4) | |
Neural invasion, n (%) | 0.736 | ||
Negative | 15 (42.9) | 26 (39.4) | |
Positive | 20 (57.1) | 40 (60.6) | |
Lymphatic invasion, n (%) | 0.001 | ||
Negative | 22 (62.9) | 12 (18.2) | |
Positive | 13 (37.1) | 54 (81.8) | |
Positive lymph node, n (%) | 0.001 | ||
Negative | 22 (62.9) | 14 (21.2) | |
Positive | 13 (37.1) | 52 (78.8) | |
Differentiated degree, n (%) | 0.16 | ||
Poorly | 27 (77.1) | 58 (87.9) | |
Moderately and highly | 8 (22.9) | 8 (12.1) | |
Lauren’s Classification, n (%) | 0.569 | ||
Intestinal | 23 (65.7) | 47 (71.2) | |
Diffuse | 12 (34.3) | 19 (28.8) |
Characteristics | Univariate analysis | Multivariate analysis | ||
Hazard ratio (95%CI) | P value | Hazard ratio (95%CI) | P value | |
Age | ||||
< 60 | 1 | |||
≥ 60 | 1.33 (0.82-2.17) | 0.25 | ||
Gender | ||||
Female | 1 | |||
Male | 1.13 (0.63-2.05) | 0.679 | ||
TNM stage | ||||
I-II | 1 | |||
III-IV | 7.07 (3.47-14.41) | < 0.001 | 3.61 (1.37-9.49) | 0.009 |
pT stage | ||||
T1-T2 | 1 | |||
T3-T4 | 1.87 (0.81-4.35) | 0.143 | ||
pN stage | ||||
N0 | 1 | |||
N1-N3 | 1.72 (1.38-2.15) | < 0.001 | 1.66 (0.68-4.07) | 0.265 |
Metastasis | ||||
M0 | 1 | |||
M1 | 4.85 (2.24-10.46) | < 0.001 | 3.07 (1.33-7.1) | 0.009 |
Tumor size | ||||
< 5 | 1 | |||
≥ 5 | 1.63 (0.97-2.72) | 0.063 | ||
Tumor location | ||||
Antrum | 1 | |||
Body | 0.92 (0.53-1.60) | 0.76 | ||
Cardia | 1.13 (0.58-2.23) | 0.72 | ||
Venous invasion | ||||
Negative | 1 | |||
Positive | 5.01 (1.57-15.98) | 0.007 | 1.69 (0.49-5.84) | 0.409 |
Neural invasion | ||||
Negative | 1 | |||
Positive | 1.73 (1.03-2.9) | 0.037 | 1.71 (0.98-3) | 0.06 |
Lymphatic invasion | ||||
Negative | 1 | |||
Positive | 3.53 (1.88-6.64) | < 0.001 | 0.39 (0.09-1.77) | 0.225 |
Positive lymph node | ||||
Negative | ||||
Positive | 3.35 (1.82-6.18) | < 0.001 | 2.23 (0.58-8.49) | 0.241 |
Differentiated degree | ||||
Moderately and highly | 1 | |||
Poorly | 0.62 (0.29-1.30) | 0.203 | ||
Lauren’s Classification | ||||
Diffuse type | 1 | |||
Intestinal type | 0.97 (0.57-1.64) | 0.908 | ||
0.97 (0.57-1.64) | ||||
NPAS2 expression | ||||
Low | 1 | |||
High | 5.13 (2.6-10.13) | < 0.001 | 2.43 (1.15-5.13) | 0.020 |
- Citation: Cao XM, Kang WD, Xia TH, Yuan SB, Guo CA, Wang WJ, Liu HB. High expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer: A single-center study. World J Gastroenterol 2023; 29(23): 3645-3657
- URL: https://www.wjgnet.com/1007-9327/full/v29/i23/3645.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i23.3645