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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
High expression of the circadian clock gene NPAS2 is associated with progression and poor prognosis of gastric cancer: A single-center study
Xiao-Meng Cao, Wen-Di Kang, Tian-Hong Xia, Shao-Bin Yuan, Chang-An Guo, Wen-Jie Wang, Hong-Bin Liu
Xiao-Meng Cao, Department of General Surgery, Gansu Provincial Hospital of TCM, Lanzhou 730050, Gansu Province, China
Xiao-Meng Cao, Shao-Bin Yuan, The First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou 730030, Gansu Province, China
Wen-Di Kang, Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Tian-Hong Xia, Clinical Medicine College, Ningxia Medical University, Clinical Medicine college, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Chang-An Guo, Department of Emergency, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Wen-Jie Wang, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, Gansu Province, China
Hong-Bin Liu, Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China. 1554153823@qq.com
Author contributions: Cao XM and Kang WD contributed equally to this work and share first authorship; Cao XM, Kang WD, and Liu HB designed the project and reviewed and edited the manuscript; Cao XM and Kang WD analyzed the data and wrote the main manuscripts; Xia TH and Yuan SB carried out research selection and data collection; Guo CA, Wang WJ and Liu HB participated in the discussion of classification criteria.
Institutional review board statement: The studies involving human participants were reviewed and approved by Medical Ethics Committee of the Second Hospital of Lanzhou University, approval No. 2021A-561. The patients/participants provided written informed consent to participate in this study.
Informed consent statement: The Medical Ethics Committee of the Second Hospital of Lanzhou University waived the need for informed consent due to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare no conflict of interest.
Corresponding author: Hong-Bin Liu, MD, Professor, Department of General Surgery, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, No. 333 Nanbinhe Road, Qilihe District, Lanzhou 730050, Gansu Province, China. 1554153823@qq.com
Received: February 9, 2023
Peer-review started: February 9, 2023
First decision: March 9, 2023
Revised: March 16, 2023
Accepted: May 4, 2023
Article in press: May 4, 2023
Published online: June 21, 2023
ARTICLE HIGHLIGHTS
Research background
The circadian clock gene NPAS2 expression is associated with multiple tumor prognosis, its role in gastric cancer (GC) is unknown.
Research motivation
NPAS2 can improve the accuracy of GC prognosis prediction and assist clinicians in postoperative patient management and decision-making.
Research objectives
This study aimed to explore the relationship between the circadian clock gene NPAS2 and the survival prognosis of GC patients and clarify its role in evaluating GC prognosis.
Research methods
Immunohistochemical staining was used to detect the expression of NPAS2 protein in GC and adjacent tissues. Univariate and multivariate Cox regression analysis was used to determine the independent prognostic factors of GC, and a nomogram prediction model was established. The receiver operating characteristic curve and area under the curve, the calibration curve, and C-index were used to evaluate the predictive effectiveness of the model.
Research results
The NPAS2 expression were independent prognostic factors of overall survival in GC patients for 3 years.
Research conclusions
NPAS2 is highly expressed in GC and is closely related to worse overall survival in patients. Therefore, the evaluation of NPAS2 expression may be a potential marker for GC prognosis evaluation.
Research perspectives
Based on NPAS2 expression, clinicians can predict patient prognosis and guide clinical decision making and follow up.
