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©The Author(s) 2022.
World J Gastroenterol. Jul 28, 2022; 28(28): 3682-3694
Published online Jul 28, 2022. doi: 10.3748/wjg.v28.i28.3682
Published online Jul 28, 2022. doi: 10.3748/wjg.v28.i28.3682
Table 1 Demographic and clinical data of patients
Variables | Total | H. pylori+ | H. pylori- | P value |
Patients, n | 1015 | 854 | 161 | |
Age in year, median (IQR) | 11 (9-13) | 11 (9-13) | 9 (6-12) | < 0.001a |
Sex, n (%) | ||||
Female | 411 (40.49) | 346 (40.52) | 65 (40.37) | |
Male | 604 (59.51) | 508 (59.48) | 96 (59.63) | 0.973 |
Endoscopic pattern, n (%) | ||||
Esophagitis | 28 (2.76) | 23 (2.69) | 5 (3.11) | 0.975 |
Superficial gastritis | 331 (32.61) | 255 (29.86) | 76 (47.20) | < 0.001b |
Superficial gastritis with erosion | 236 (23.25) | 200 (23.42) | 36 (22.36) | 0.77 |
Superficial gastritis with bile reflux | 295 (29.06) | 251 (29.39) | 44 (27.33) | 0.597 |
Antral nodularity | 135 (13.30) | 131 (15.34) | 4 (2.48) | < 0.001b |
Peptic ulcer | 90 (8.87) | 80 (9.37) | 10 (6.21) | 0.196 |
Atrophic gastritis | 18 (1.77) | 17 (1.99) | 1 (0.62) | 0.378 |
Clinical diagnosis, n (%) | ||||
Esophagitis | 28 (2.76) | 23 (2.69) | 5 (3.11) | 0.975 |
Non atrophic gastritis | 997 (98.23) | 837 (98.01) | 160 (99.38) | 0.378 |
Atrophic gastritis | 18 (1.77) | 17 (1.99) | 1 (0.62) | 0.378 |
Gastric ulcer | 18 (1.77) | 16 (1.87) | 2 (1.24) | 0.817 |
Duodenal ulcer | 72 (7.09) | 64 (7.49) | 8 (4.97) | 0.252 |
Table 2 Helicobacter pylori infection status in different age groups
Table 3 Precancerous lesions in the gastric mucosa in children and adolescents
Age group | H. pylori+ | Subtotal | H. pylori- | Subtotal | ||||||
n | Atrophy | IM | Dysplasia | n | Atrophy | IM | Dysplasia | |||
1-4 | 22 | 1 | 1 | 1 | 3 | 32 | 0 | 0 | 0 | 0 |
5-8 | 156 | 4 | 4 | 1 | 9 | 43 | 0 | 0 | 0 | 0 |
9-12 | 383 | 6 | 3 | 6 | 15 | 52 | 0 | 0 | 0 | 0 |
13-18 | 293 | 6 | 3 | 1 | 10 | 34 | 1 | 0 | 0 | 1 |
Total | 854 | 37 (4.33%)a | 161 | 1 (0.62%) |
Table 4 Comparison of active inflammation between Helicobacter pylori-positive and -negative patients
Age group | H. pylori+ | H. pylori- | ||||
n | Active inflammation | Non-active inflammation | n | Active inflammation | Non-active inflammation | |
1-4 | 22 | 3 (13.64) | 19 (86.36) | 32 | 2 (6.25) | 30 (93.75) |
5-8 | 156 | 23 (14.74)a | 133 (85.26) | 43 | 1 (2.33) | 42 (97.67) |
9-12 | 383 | 52 (13.58)b | 331 (86.42) | 52 | 2 (3.85) | 50 (96.15) |
13-18 | 293 | 59 (20.14)c | 234 (79.86) | 34 | 1 (2.94) | 33 (97.06) |
Total | 854 | 137 (16.04)d | 717 (83.96) | 161 | 6 (3.73) | 155 (96.27) |
Table 5 Degree of neutrophil granulocyte infiltration in Helicobacter pylori-positive and -negative patients
Age group | H. pylori+ | H. pylori+ | Z | P value | ||||||
n | Absent | Mild | Moderate | n | Absent | Mild | Moderate | |||
1-4 | 22 | 19 (86.36) | 3 (13.64) | 0 (0) | 32 | 30 (93.75) | 2 (6.25) | 0 (0) | 0.912 | 0.362 |
5-8 | 156 | 133 (85.26) | 21 (13.46) | 2 (1.28) | 43 | 42 (97.67) | 1 (2.33) | 0 (0) | 2.212 | 0.027a |
9-12 | 383 | 331 (86.42) | 44 (11.49) | 8 (2.09) | 52 | 50 (96.15) | 2 (3.85) | 0 (0) | 2.009 | 0.045b |
13-18 | 293 | 234 (79.86) | 48 (16.38) | 11 (3.76) | 34 | 33 (97.06) | 1 (2.94) | 0 (0) | 2.456 | 0.014c |
Total | 854 | 717 (83.96) | 116 (13.58) | 21 (2.46) | 161 | 155 (96.27) | 6 (3.73) | 0 (0) | 4.319 | < 0.001d |
Table 6 Degree of lymphocyte infiltration in Helicobacter pylori-positive and -negative patients
Age group | H. pylori+ | H. pylori- | Z | P value | ||||||
n | Mild | Moderate | Marked | n | Mild | Moderate | Marked | |||
1-4 | 22 | 10 (45.45) | 11 (50) | 1 (4.55) | 32 | 17 (53.12) | 14 (43.75) | 1 ( 3.13) | 0.57 | 0.569 |
5-8 | 156 | 67 (42.95) | 75 (48.08) | 14 (8.97) | 43 | 24 (55.81) | 18 (41.86) | 1 (2.33) | 1.737 | 0.082 |
9-12 | 383 | 161 (42.04) | 195 (50.91) | 27 (7.05) | 52 | 31 (59.62) | 20 (38.46) | 1 (1.92) | 2.539 | 0.01a |
13-18 | 293 | 112 (38.23) | 151 (51.54) | 30 (10.24) | 34 | 19 (55.88) | 14 (41.18) | 1 (2.94) | 2.164 | 0.03b |
Total | 854 | 350 (40.98) | 432 (50.59) | 72 (8.43) | 161 | 91 (56.52) | 66 (40.99) | 4 (2.48) | 3.997 | < 0.00c |
- Citation: Yu M, Ma J, Song XX, Shao QQ, Yu XC, Khan MN, Qi YB, Hu RB, Wei PR, Xiao W, Jia BL, Cheng YB, Kong LF, Chen CL, Ding SZ. Gastric mucosal precancerous lesions in Helicobacter pylori-infected pediatric patients in central China: A single-center, retrospective investigation. World J Gastroenterol 2022; 28(28): 3682-3694
- URL: https://www.wjgnet.com/1007-9327/full/v28/i28/3682.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i28.3682