Published online Jul 28, 2022. doi: 10.3748/wjg.v28.i28.3682
Peer-review started: January 9, 2022
First decision: March 8, 2022
Revised: April 2, 2022
Accepted: June 21, 2022
Article in press: June 21, 2022
Published online: July 28, 2022
Chronic Helicobacter pylori (H. pylori) infection causes gastric mucosal precancerous lesions and gastric cancer in adult patients. It remains to be determined, however, whether gastric mucosal precancerous lesions may also occur in children and adolescents, as this remains an important issue for clinical intervention.
Investigating the relationship between H. pylori infection and gastric mucosal precancerous lesions in pediatric patients will provide important evidence on whether intervention should be offered to prevent related disease development in this population group.
H. pylori infection status, gastric mucosal inflammation and gastric precancerous lesions in hospitalized pediatric patients were investigated in central China.
We retrospectively enrolled 1015 symptomatic pediatric patients to analyze their clinical and path-ological data. The endoscopic and histological findings, occurrence of gastric mucosal precancerous lesions, inflammatory activity and degree of inflammatory cell infiltration were analyzed between H. pylori-positive and -negative patient groups.
The overall H. pylori infection rate was 84.14% for the 1015 enrolled pediatric patients, and infection rate increased with age. The incidence of gastric mucosal precancerous lesions in H. pylori-infected children was 4.33%, which was significantly higher than that in H. pylori-negative children. Infected patients showed more active inflammation as well as more severe inflammatory cell infiltration compared to the non-infected patients. Additionally, endoscopy revealed that the most common presentation was antral nodularity in H. pylori-positive patients, whereas superficial gastritis was a marked feature for H. pylori-negative patients.
In children and adolescents, gastric mucosal precancerous lesions occurred in 4.33% of H. pylori-infected patients in central China. The data revealed an obvious critical issue that requires future investigation and intervention for this population group.
The results provide insights on H. pylori infection status and its relationship with gastric mucosal precancerous in symptomatic pediatric patients in central China. Further investigation and intervention for related disease prevention are required in this population group.