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©The Author(s) 2022.
World J Gastroenterol. Jul 7, 2022; 28(25): 2890-2899
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2890
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2890
Table 1 Genetic polymorphisms involved in non-alcoholic fatty liver disease occurrence and related phenotypes
Gene | Variant (s) | Function | Phenotype |
PNPLA3 | rs738409 C>G | Triglyceride hydrolysis | ↑ NAFLD, NASH, fibrosis, HCC |
TM6SF2 | rs58542926 C>T | Lipoproteins secretion | ↑ NAFLD, NASH, fibrosis |
GCKR | rs1260326 C>Trs780094 A>G | De novo lipogenesis regulation | ↑ NAFLD, NASH, fibrosis |
MBOAT7 | rs641738 C>T | Phospholipid metabolism | ↑ NAFLD and fibrosis |
HSD17B13 | rs72613567:TA | Conversion of retinol to retinoic acid | ↓ NASH and fibrosis |
FNDC5 | rs3480 A>G | Hepatic fibrogenesis | ↓ fibrosis |
- Citation: Wajsbrot NB, Leite NC, Salles GF, Villela-Nogueira CA. Non-alcoholic fatty liver disease and the impact of genetic, epigenetic and environmental factors in the offspring. World J Gastroenterol 2022; 28(25): 2890-2899
- URL: https://www.wjgnet.com/1007-9327/full/v28/i25/2890.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i25.2890