Non-alcoholic fatty liver disease and the impact of genetic, epigenetic and environmental factors in the offspring

Table 1 Genetic polymorphisms involved in non-alcoholic fatty liver disease occurrence and related phenotypes

Gene	Variant (s)	Function	Phenotype
PNPLA3	rs738409 C>G	Triglyceride hydrolysis	↑ NAFLD, NASH, fibrosis, HCC
TM6SF2	rs58542926 C>T	Lipoproteins secretion	↑ NAFLD, NASH, fibrosis
GCKR	rs1260326 C>Trs780094 A>G	De novo lipogenesis regulation	↑ NAFLD, NASH, fibrosis
MBOAT7	rs641738 C>T	Phospholipid metabolism	↑ NAFLD and fibrosis
HSD17B13	rs72613567:TA	Conversion of retinol to retinoic acid	↓ NASH and fibrosis
FNDC5	rs3480 A>G	Hepatic fibrogenesis	↓ fibrosis

rs: Reference SNP; NAFLD: Non-alcoholic fatty liver disease; NASH: Non-alcoholic steatohepatitis; HCC: Hepatocellular carcinoma.