Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression

Table 1 The expression of small nucleolar RNA host gene 3 and its clinical significance in liver cancer and other cancers

Cancer types	Cases	Expression	Clinicopathologic parameters	PMID
Hepatocellular carcinoma	47 pairs	Upregulated	Tumor stage, lymph node metastasis, distant metastasis	31548493
Hepatocellular carcinoma	195 pairs	Upregulated	Tumor size, PVTT, relapse	26373735
Breast cancer	30 pairs	Upregulated		32495883
Breast cancer	60 pairs	Upregulated	Histological grade, TNM stage, lymph node metastasis, ER, Her-2	31586299
Breast cancer	60 pairs	Upregulated		32883233
Breast cancer	48 pairs	Upregulated		32945476
Cervical cancer	88 pairs	Upregulated	FIGO stage, metastasis	34816392
Clear cell renal cell carcinoma	36 pairs	Upregulated	Distant metastasis, T stage, pathological TNM stage, histologic grade	31505165
Colorectal cancer	58 pairs	Upregulated	Tumor stage, distant metastasis	32187965
	50 pairs	Upregulated		34661273
Esophageal cancer	384 pairs	Upregulated		33596916
Gastric cancer	60 pairs	Upregulated		32930970
Glioma	42 pairs	Upregulated	Tumor size, WHO grade	33817254
Glioma	8 low-grade and 8 high-grade and 8 normal tissues	Upregulated		34153159
Laryngeal carcinoma	18 pairs	Upregulated		31238052
Laryngeal carcinoma	25 pairs	Upregulated		32538668
Lung Adenocarcinoma	65 pairs	Downregulated	TNM stage, lymph node metastasis	32538668
Non-small-cell lung cancer	35 pairs	Upregulated	TNM stage, lymph node metastasis, tumor size	34132359
Non-small-cell lung cancer	32 pairs	Upregulated	TNM stage, lymph node metastasis, tumor size	31602642
Non-small-cell lung cancer	42 pairs	Upregulated	Stage, lymph node metastasis	33177840
Non-small-cell lung cancer	15 pairs	Upregulated		34032148
Oral squamous cell carcinoma	30 pairs	Upregulated		32989886
Osteosarcoma	54 pairs	Upregulated		30797154
Osteosarcoma	127 pairs	Upregulated		30791797
Ovarian cancer	18 pairs	Upregulated		29921511
Ovarian cancer	96 pairs	Upregulated	FIGO stage, histological grade, lymph node metastasis	33149611
Ovarian cancer	76 pairs	Upregulated	FIGO stage, lymph node metastasis	29758922
Ovarian cancer	40 patients with OC and 19 patients with benign OC	Upregulated		33552243
Papillary thyroid carcinoma	72 pairs	Upregulated	TNM stage, lymph node metastasis	32048306
Prostate cancer	50 pairs	Upregulated		33416420

PVTT: Portal vein tumor thrombosis; TNM: Tumor-node-metastasis; FIGO: International Federation of Gynecology and Obstetrics; WHO: World Health Organization.

Table 2 Function and mechanism of small nucleolar RNA host gene 3 in liver cancer and other cancers

Cancer types	Assessed cancer cell lines	Expression	Related genes and pathways	Biological significance	PMID
Hepatocellular carcinoma	PLC/PRF/5, Hep3B, HepG2, MHCC97L, Huh7, SMMC-7721, HCCLM3	Up	miR-128, CD151	Invasion, EMT, sorafenib resistance	30132868
Hepatocellular carcinoma	HepG2, HCCLM3	Up	miR-326, SMAD3, ZEB1	Proliferation, migration, EMT, anti-apoptosis	31548493
Hepatocellular carcinoma	HepG2, HuH-7	Up	miR-214-3p, ASF1B		34336642
Acute myeloid leukemia	HL-60,THP-1,KG-1, NB4, MOLM-14	Up	miR-758-3p, SRGN	Proliferation, anti-apoptosis	31452272
Bladder cancer	5637,T24	Up	miR-515-5p, GINS2	Proliferation, migration, invasion, EMT	32596993
Breast cancer	MCF-7, MD-MBA-453	Up	miR-330, PKM	Proliferation, mitochondrial metabolism	31956955
Breast cancer	MDA-MB-231, BT-549, MDA-MB-468	Up	miR-326, ITGA5 Vav2/Rac1	Viability, migration, invasion, anti-apoptosis	32495883
Breast cancer	MDA-MB-231, MCF-7	Up	miR-384, HDGF	Proliferation, migration, invasion	31586299
Breast cancer	MCF-7, MDA-MB-231, HCC1937, BT474, SKBr-3	Up	miR-154-3p, Notch	Proliferation, migration, invasion	32883233
Breast cancer	MDA-MB-231, MCF-7	Up	miR-186-5p, ZEB1	Proliferation, migration, invasion	33594311
Breast cancer	MCF-7, MDA-MB-231, MDA-MB-468, BT-474	Up	miR-326	Proliferation, migration, invasion	32945476
Cervical cancer	C33A, HeLa, SiHa, CaSki and HCC94	Up	YAP1	Proliferation, migration, invasion	34816392
Cervical cancer	SiHa	Up		Proliferation, migration, invasion	34238747
Cholangiocarcinoma	HCCC9810, QBC939, RBE, HUCCT1	Up	miR-3173–5p, ERG	Proliferation, migration, invasion	34647226
Clear cell renal cell carcinoma	ACHN, A498, Caki-1	Up	miR-139-5p, TOP2A	Proliferation, migration, invasion	31505165
Colorectal cancer	HCT116, LoVo, SW480, and SW620	Up	miR-539, RUNX2	Proliferation, migration, invasion	32187965
Colorectal cancer	HT29, HCT116, SW480, and LoVo	Up	miR-182-5p, c-Myc	Proliferation, migration, invasion	28731158
Colorectal cancer	SW480, SW620, HCT8, HT29	Up	miR-370-5p, EZH1	Proliferation, migration, invasion	34661273
Esophageal cancer	KYSE-150, Eca-9706	Up	miR-186-5p, METTL3, m6A		33596916
Gastric cancer	MGC-803, AGS, BGC-823, SGC-7901, MKN-45, HGC-27	Up	EZH2, MED18	Proliferation, migration, invasion	31534128
Gastric cancer	SGC7901, BGC823	Up	IL-6, STAT3, SNHG3, miR-3619-5p, ARL2	Proliferation	32930970
Gastric cancer	HGC-27, GC9811-P	Up	miR-326, TWIST	Proliferation, migration, invasion	34257656
Glioma	A172, SHG44	Up	miR-384, HDGF	Proliferation, migration, invasion, anti-apoptosis	33817254
Glioma	U-87-MG, U-251-MG	Up	miR-485-5p, LMX1B	Proliferation, migration, invasion	34153159
Laryngeal carcinoma	16HBE, TU212, TU686	Up	miR-384, WEE1	Proliferation, migration, invasion	31238052
Laryngeal carcinoma	TU177, AMC-HN-8	Up	Wnt/β-catenin, miR-340-5p, YAP1	Proliferation, migration, anti-apoptosis, mitochondrial metabolism	32538668
Lung adenocarcinoma	A549, H1299	Up		Proliferation, cell cycle,anti-apoptosis	30154938
Lung adenocarcinoma	A549, H1299, H1975	Down	miR-890	Anti-proliferation, anti-migration, anti-invasion, apoptosis	34306585
Non-small-cell lung cancer	H1299, H358, A549, H1975	Up	miR-13433p, NFIX	Proliferation, migration, invasion	34132359
Non-small-cell lung cancer	CMT-167, LLC, CMT-170, CMT-181	Up	TGF-β pathway, IL-6, JAK2, STAT3 pathway	Proliferation, migration, EMT	31602642
Non-small-cell lung cancer	SPC-A1, A549, NCI-H23, NCI-H460	Up	miR-340-5p	Lymph node infiltration, distant metastases	33225676
Non-small-cell lung cancer	A549, H322, H1299, GLC-82, SPC-A1	Up	miR-216a, ZEB1	Proliferation, migration, invasion	33177840
Non-small-cell lung cancer	A549, HCC827, H2170, H520	Up	miR-515-5p, SUMO2	Proliferation, migration, invasion, EMT	34032148
Oral squamous cell carcinoma	SCC4, CAL-27	Up	miR-2682-5p, HOXB8	Proliferation, migration	32989886
Oral squamous cell carcinoma	SCC-15, SCC-9, CAL-27, HN5	Up	Wnt/β-catenin, NFYC	Proliferation, migration	31762107
Osteosarcoma	Saos2, MG63, U2OS, HOS	Up	miR-151a-3p, RAB22A	Proliferation, migration, invasion	30797154
Osteosarcoma	MG-63, 143B, HOS, SW-1353, Saos-2, U-2OS	Up	miR-196a-5p	Proliferation, colony formation	30791797
Ovarian cancer	SK-OV3, TOV-21G, and OVCAR-3	Up		Energy metabolism	29921511
Ovarian cancer	SKOV3, HeyA8, A2780	Up	miR-339-5p, TRPC3	Proliferation, anti-apoptosis	33149611
Ovarian cancer	SKOV3, 60OVCAR3, A2780, ES2	Up	GSK3β/β-catenin	Proliferation, migration	29758922
Ovarian cancer	A2780, SKOV3, OVCAR3, OV90	Up	miR-139-5p, Notch1	Proliferation, migration	33552243
Papillary thyroid carcinoma	BCPAP, TPC-1	Up	miR-214-3p, PSMD10	Migration, invasion, proliferation, and colony formation	32048306
Prostate cancer	PC3, DU145, 22RV1, NCaP	Up	miR-577, SMURF1	Proliferation, migration, EMT, anti-apoptosis	32248648
Prostate cancer	PC3, 22RV1, DU145, LNCaP	Up	miR-487a-3p,TRIM25	Viability, migration, invasion, EMT	33416420

EMT: Epithelial–mesenchymal transition.