Review
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World J Gastroenterol. Apr 28, 2022; 28(16): 1641-1655
Published online Apr 28, 2022. doi: 10.3748/wjg.v28.i16.1641
Small nucleolar RNA host gene 3 functions as a novel biomarker in liver cancer and other tumour progression
Dan-Dan Shan, Qiu-Xian Zheng, Jing Wang, Zhi Chen
Dan-Dan Shan, Qiu-Xian Zheng, Jing Wang, Zhi Chen, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Chen Z carried out the concepts and designed the definition of intellectual content; Shan DD and Zheng QX carried out the literature search and manuscript editing; Wang J performed manuscript review; All authors have read and approved the content of the manuscript.
Supported by the National Science and Technology Major Project of China, No. 2018ZX10302206 and 2017ZX10202203.
Conflict-of-interest statement: The authors declare that there is no conflict of interests regarding the publication of this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi Chen, MD, PhD, Professor, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. zjuchenzhi@zju.edu.cn
Received: January 18, 2022
Peer-review started: January 18, 2022
First decision: February 7, 2022
Revised: February 9, 2022
Accepted: March 16, 2022
Article in press: March 16, 2022
Published online: April 28, 2022
Processing time: 96 Days and 3.3 Hours
Core Tip

Core Tip: This review explores the differential expression of small nucleolar RNA host gene 3 (SNHG3) as a novel lncRNA in hepatocellular carcinoma as well as other tumours. SNHG3 is upregulated in most tumours and can influence tumourigenesis and progression through competing endogenous RNA effects and signalling pathways, thereby adversely affecting patient prognosis. Therefore, SNHG3 may become a new target for the diagnosis and treatment of many cancers, including hepatocellular carcinoma.