Establishing a rabbit model of perianal fistulizing Crohn’s disease

Table 1 The volume of 2,4,6-trinitrobenzene sulfonic acid mixture administered by enema in each group

	Day 1	Day 7	Day 14
Group A (n = 9)	4.0 mL	5.0 mL	6.0 mL
Group B (n = 9)	5.0 mL	5.0 mL	5.0 mL
Group C (n = 2)	-	-	-

Table 2 Identification of the rabbit model of Crohn's disease induced by 2,4,6-trinitrobenzene sulfonic acid

	Group	Day 7	P value	Day 14	P value	Day 21	P value	Day 28	P value
DAI	A	4.22 ± 2.33	0.026	6.88 ± 0.93	0.020	8.00 ± 2.00	0.810	7.78 ± 1.56	0.021
	B	7.13 ± 2.53		8.75 ± 1.91		8.25 ± 2.25		5.75 ± 1.67
Endoscopy scores	A	1.11 ± 0.78	0.002	2.44 ± 0.88	0.319	3.89 ± 0.93	< 0.001
	B	2.88 ± 1.13		2.88 ± 0.83		1.63 ± 0.92
Histology scores	A	1.44 ± 0.88	< 0.001	3.11 ± 0.93	0.017	4.11 ± 0.78	< 0.001
	B	3.50 ± 0.93		2.00 ± 0.76		1.88 ± 0.99

DAI: Disease activity index.