Impact of Helicobacter pylori infection on gut microbiota

Table 1 Studies for the influence of Helicobacter pylori infection on gut microbiota

Ref.	Study groups H. pylori (+) vs (-)	Aim	Main findings for H. pylori positive subject
Bühling et al[7], 2001	51 vs 27	Sub analysis for eradication study	L. acidophilus ↑
Myllyluoma et al[8], 2007	39 vs 19	Sub analysis for eradication study	Clostridia ↓, Anaerobes ↓
Chen et al[9], 2018	70 vs 35	Sub analysis for eradication study	Diversity ↑, Nitrospirae ↓, the relative abundance of 19 pathways were significantly different between H. pylori-negative and H. pylori-positive patients
Iino et al[5], 2018	226 vs 524	Analysis of microbiota without eradication	Lactobacillus ↑
He et al[10], 2019	10 vs 7	Sub analysis for eradication study	Diversity ↑, Proteobacteria ↑
Iino et al[6], 2020	214 vs 214	Analysis of microbiota without eradication	Diversity ↑, Haemophilusu ↑, Streptococcus ↑, Gemella ↑, Actinomyces ↑
Martín-Núñez et al[11], 2019	40 vs 20	Sub analysis for eradication study	Diversity ↓, Oscillospira ↓
Dash et al[12], 2019	12 vs 48	Analysis of microbiota without eradication	Diversity ↑, Succinivibrio ↑, Coriobacteriaceae ↑, Enterococcaceae ↑, Rikenellaceae ↑, Candida glabrata ↑
Frost et al[13], 2019	212 vs 212	Analysis of microbiota without eradication	Diversity ↑, Prevotella ↑, Bacteroidetes ↓, Parasutterella ↑, Holdemanella ↑, Betaproteobacteria ↑, Pseudoflavonifractor ↓, Alisonella ↑, Howardella ↑

Helicobacter pylori: H. pylori.