Modulation of cell physiology under hypoxia in pancreatic cancer

Table 1 List of oncogenic and tumor suppressor microRNAs in pancreatic cancer cells under hypoxia

MicroRNA	Oncogenic activity	Function	Ref.
miR-519	Anti-tumor	Inhibits cell growth and invasiveness	[138]
miR-58an	Anti-tumor	Reduces tumorigenesis	[139]
miR-454	Anti-tumor	Decreases cell proliferation	[140]
miR-210	Pro-tumor	Regulates cell cycle and promotes angiogenesis	[142]
miR-191	Pro-tumor	Promotes tumor growth, invasion, and metastasis	[143]
miR-212	Pro-tumor	Promotes tumor growth, vessel invasion, and metastasis	[144]
miR-21	Pro-tumor	Induces cell proliferation, invasion, and metastasis	[119,145]
miR-210	Pro-tumor	Increases migration, invasion, and angiogenesis	[119]
miR-646	Pro-tumor	Promotes proliferation and invasion	[147]
miR-125a	Pro-tumor	Increases tumor cell viability	[148]
miR-96-5p	Anti-tumor	Inhibits angiogenesis	[132]
miR-153	Anti-tumor	Avoids immune escape of tumor cells from natural killer cells	[146]