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©The Author(s) 2021.
World J Gastroenterol. Jun 7, 2021; 27(21): 2910-2920
Published online Jun 7, 2021. doi: 10.3748/wjg.v27.i21.2910
Published online Jun 7, 2021. doi: 10.3748/wjg.v27.i21.2910
Table 1 Clinical characteristics of patients with chronic hepatitis B virus infection
Parameter | HBeAg-positive patients (n = 402) | HBeAg-negative patients (n = 248) | P value |
Gender, male | 79.4.4% (319/402) | 76.2% (189/248) | 0.38 |
Age (yr) | 36.35 ± 10.36 | 41.67 ± 9.65 | < 0.001 |
BMI (kg/m2) | 23.12 ± 3.31 | 23.62 ± 2.84 | 0.01 |
HBsAg (log10 IU/mL) | 3.83 ± 0.81 | 3.16 ± 0.73 | < 0.001 |
HBV DNA (log10IU/mL) | 6.93 ± 1.66 | 4.82 ± 1.64 | < 0.001 |
ALT (U/L) | 106.74 ± 139.40 | 80.58 ± 105.61 | < 0.001 |
AST (U/L) | 65.48 ± 78.67 | 56.69 ± 70.06 | 0.029 |
TC (mmol/L) | 4.61 ± 3.05 | 4.44 ± 0.98 | 0.691 |
TBil (μmol/L) | 16.54 ± 15.48 | 18.49 ± 27.32 | 0.009 |
DBil (μmol/L) | 5.61 ± 7.54 | 5.77 ± 6.59 | 0.527 |
Albumin (g/L) | 43.72 ± 5.14 | 44.91 ± 6.07 | 0.011 |
PT (s) | 12.81 ± 1.49 | 12.55 ± 1.49 | 0.035 |
Cr (μmol/L) | 70.21 ± 25.41 | 69.19 ± 15.93 | 0.818 |
BUN (mmol/L) | 5.28 ± 5.57 | 4.90 ± 1.33 | 0.681 |
Platelet counts (× 109/L) | 178.6 ± 56.18 | 158.5 ± 55.28 | < 0.001 |
Histology (n, %) | |||
HAI 0-4 | 38.31% (154/402) | 44.35% (110/248) | 0.14 |
HAI ≥ 5 | 61.69% (248/402) | 55.64% (138/248) | |
Fibrosis score 0-2 | 38.06% (153/402) | 59.27% (147/248) | < 0.001 |
Fibrosis score ≥ 3 | 61.49% (249/402) | 40.73% (101/248) |
Table 2 Selected features for predicting moderate-to-severe inflammation in patients with chronic hepatitis B virus infection (more than 40 votes)
Feature name | HBeAg-positive patients | HBeAg-negative patients | ||||
Votes | Spearman’r (95%CI)1 | P value1 | Votes | Spearman r (95%CI)1 | P value1 | |
ALT | 100 | 0.45 (0.36-0.53) | < 0.001 | 100 | 0.44 (0.33-0.53) | < 0.001 |
AST | 100 | 0.51 (0.43-0.58) | < 0.001 | 100 | 0.49 (0.38-0.58) | < 0.001 |
qAnti-HBc | 100 | 0.55 (0.47-0.62) | < 0.001 | 100 | 0.49 (0.39-0.58) | < 0.001 |
CXCL10 | 46 | 0.34 (0.25-0.43) | < 0.001 | 51 | 0.35 (0.23-0.46) | < 0.001 |
CXCL11 | 100 | 0.34 (0.25-0.43) | < 0.001 | 100 | 0.33 (0.21-0.44) | < 0.001 |
IL-2R | 71 | 0.30 (0.20-0.39) | < 0.001 | 44 | 0.27 (0.14-0.38) | < 0.001 |
CCL2 | 42 | -0.01 (-0.09-0.07) | 0.79 | 52 | 0.03 (-0.10-0.16) | 0.65 |
TNF-α | 56 | 0.01 (-0.17-0.09) | 0.78 | 62 | 0.01 (-0.17-0.09) | 0.78 |
IL-1β | 27 | -0.10 (-0.23-0.03) | 0.12 | 54 | 0.15 (0.03-0.28) | 0.02 |
Table 3 Receiver operating characteristic curve analysis of inflammation scores in patients with chronic hepatitis B virus infection
Cutoff value | Se (%) | Spe (%) | PPV (%) | NPV (%) | Accuracy (%) | AUROC (95%CI) | P value | |
All patients | ||||||||
I-3A | < 0.41 | 69.17 | 81.44 | 84.49 | 64.37 | 73.8 | 0.82 (0.79-0.85) | < 0.0001 |
qAnti-HBc | > 4.20 log10 IU/mL | 83.94 | 55.68 | 73.47 | 70.33 | 72.13 | 0.76 (0.72-0.79) | |
HBeAg-positive patients | ||||||||
I-3A | < 0.41 | 70.16 | 80.52 | 85.29 | 62.63 | 74.13 | 0.83 (0.79-0.87) | < 0.0001 |
qAnti-HBc | > 4.20 log10 IU/ml | 83.06 | 60.39 | 77.15 | 68.89 | 74.38 | 0.77 (0.73-0.81) | |
HBeAg-negative patients | ||||||||
I-3A | < 0.44 | 73.19 | 78.18 | 80.8 | 69.92 | 75.4 | 0.81 (0.76-0.86) | 0.002 |
qAnti-HBc | > 4.40 log10 IU/mL | 76.81 | 61.13 | 71.62 | 68 | 70.16 | 0.75 (0.70-0.81) |
- Citation: Zhou JY, Song LW, Yuan R, Lu XP, Wang GQ. Prediction of hepatic inflammation in chronic hepatitis B patients with a random forest-backward feature elimination algorithm. World J Gastroenterol 2021; 27(21): 2910-2920
- URL: https://www.wjgnet.com/1007-9327/full/v27/i21/2910.htm
- DOI: https://dx.doi.org/10.3748/wjg.v27.i21.2910