Surgical outcome of laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass for resolution of type 2 diabetes mellitus: A systematic review and meta-analysis

Table 1 Characteristics of the nine selected studies comparing type 2 diabetes mellitus resolution by laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass in this study

Ref.	Country	Study type	Sample size		Key findings
			LSG	LRYGB
Du et al[1], 2017	China	Randomized clinical trial	19	74	Overall remission rate achieved with LRYGB and LSG was 75.9% at 1 yr and 56.4% at 3 yr
					Safety profile, T2DM resolution and other morbid obesity-related comorbidities by both procedures are comparable
Garg et al[42], 2017	India	Retrospective clinical	40	40	The median duration of T2DM was higher in LRYGB than LSG (2.2 vs 1.8), respectively
					Both LRYGB and LSG showed significant but similar improvement in T2DM remission
Park and Kim[43], 2015	South Korea	Retrospective Cohort Study	104	236	The study found comparable results with insignificant differences between LRYGB and LSG
Perrone et al[27], 2016	Italy	Prospective clinical trials	162	142	LSG is more effective in obese men than in women for excess weight loss. However, there is no difference in terms of the remission of comorbidities
					LRYGB showed similar findings in both genders for excess weight loss and comorbidity resolution, including T2DM
Perrone et al[44], 2017	Italy	Prospective clinical trial	162	142	LRYGB showed better T2DM resolution rate in the short-term
					Neither LRYGB nor LSG showed a significant difference in T2DM remission in the long-term
Praveenraj et al[14], 2016	India	Retrospective clinical trial	54	32	LRYGB showed better surgical outcomes than LSG in patients > 50 yr
					LSG had shorter operative times and shorter hospital stays
Peterli et al[45], 2018	Finland	The SLEEVEPASS multicenter, randomized clinical trial	120	120	Complete or partial remission of T2DM was reported in 37% after LSG and in 45% LRYGB. No significant difference in terms of T2DM resolution is reported between LRYGB and LSG
Wallenius et al[29], 2018	Sweden	Prospective clinical trial	15	18	There was a similar decrease in post-op fasting blood glucose in both the LRYGB and LSG groups
					LRYGB and LSG showed similar outcomes in glycemic control, with insignificant differences in short- and mid-term follow-up
Yang et al[22], 2015	China	Randomized clinical study	22	23	LSG and LRYGB had comparable effects on T2DM remission in the Chinese study cohort with a BMI of 28-35 kg/m2

LSG: Laparoscopic sleeve gastric bypass; LRYGB: Laparoscopic Roux-en-Y gastric bypass; T2DM: Type 2 diabetes mellitus.