Copyright
©The Author(s) 2020.
World J Gastroenterol. Feb 7, 2020; 26(5): 466-477
Published online Feb 7, 2020. doi: 10.3748/wjg.v26.i5.466
Published online Feb 7, 2020. doi: 10.3748/wjg.v26.i5.466
Table 1 Kyoto classification score
Kyoto classification | Score |
Atrophy | |
None, C1 | 0 |
C2 and C3 | 1 |
O1-O3 | 2 |
Intestinal metaplasia | |
None | 0 |
Antrum | 1 |
Corpus and antrum | 2 |
Enlarged folds | |
Absence | 0 |
Presence | 1 |
Nodularity | |
Absence | 0 |
Presence | 1 |
Diffuse redness | |
None | 0 |
Mild (with RAC) | 1 |
Severe | 2 |
Kyoto score | 0-8 |
Table 2 Diagnostic value of Kyoto classification for Helicobacter pylori infection
Endoscopic findings | Ref. | Year | No. of subjects | Sensitivity | Specificity | PPV | NPV |
Diagnosis for current H. pylori infection | |||||||
Enlarged folds | Kato et al[59] | 2013 | 275 | 58.5 | 79.5 | 76.9 | 62.2 |
Enlarged folds | Mao et al[60] | 2016 | 256 | 60.2 | 92.3 | 86.0 | 74.6 |
Enlarged folds | Yoshii et al[61] | 2019 | 498 | 23.1 | 96.6 | 56.2 | 87.0 |
Nodularity | Laine et al[57] | 1995 | 52 | 32.1 | 95.8 | 90.0 | 54.8 |
Nodularity | Kato et al[59] | 2013 | 275 | 5.3 | 98.8 | 75.0 | 59.4 |
Nodularity | Yoshii et al[61] | 2019 | 498 | 6.4 | 98.3 | 41.7 | 84.9 |
Diffuse redness | Kato et al[59] | 2013 | 275 | 83.4 | 66.9 | 73.8 | 78.4 |
Diffuse redness | Mao et al[60] | 2016 | 256 | 57.5 | 95.8 | 91.5 | 74.7 |
Diffuse redness | Yoshii et al[61] | 2019 | 498 | 60.0 | 94.7 | 65.6 | 93.3 |
Diagnosis for negative H. pylori infection | |||||||
RAC | Yagi et al[58] | 2002 | 557 | 91.1 | 97.9 | 95.0 | 96.2 |
RAC | Kato et al[59] | 2013 | 275 | 93.6 | 48.0 | 87.0 | 66.8 |
RAC | Mao et al[60] | 2016 | 256 | 86.7 | 90.2 | 87.5 | 89.6 |
RAC | Garcés-Durán et al[62] | 2019 | 140 | 100.0 | 49.0 | 47.3 | 100.0 |
Table 3 Gastric cancer incidence according to endoscopic atrophy
Ref. | Population | No. of subjects | No. of cancers | Duration, yr | Gastric cancer incidence, %/yr | ||
Mild | Moderate | Severe | |||||
Take et al[70], 2011 | Post eradication with peptic ulcer | 1674 | 28 | 5.6 | 0.04 | 0.28 | 0.62 |
Shichijo et al[71], 2016 | Post eradication | 573 | 21 | 6.2 | 0.071 | 0.341 | 1.601 |
Kaji et al[72], 2019 | Medical examination | 12941 | 63 | 3.7 | 0.10 | 0.16 | 0.31 |
Post eradication | 2571 | 20 | 3.7 | 0.06 | 0.12 | 0.42 |
Table 4 Odds ratios of endoscopic findings for gastric cancer
Endoscopic findings | Ref. | Population | No. of subjects | Odds ratio |
Atrophy | Masuyama et al[76], 2015 | Without eradication | 27777 | 14.21 |
Atrophy | Sekikawa et al[77], 2016 | Screening | 1823 | 7.21 |
Intestinal metaplasia | Sugimoto et al[74], 2017 | Endoscopic gastritis | 1200 | 5.0 |
Enlarged folds | Nishibayashi et al[73], 2003 | H. pylori positive | 276 | 5.0 |
Nodularity | Nishikawa et al[49], 2018 | H. pylori positive | 674 | 13.9 |
RAC | Majima et al[75], 2019 | Post eradication | 194 | 0.4 |
- Citation: Toyoshima O, Nishizawa T, Koike K. Endoscopic Kyoto classification of Helicobacter pylori infection and gastric cancer risk diagnosis. World J Gastroenterol 2020; 26(5): 466-477
- URL: https://www.wjgnet.com/1007-9327/full/v26/i5/466.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i5.466