Relationship between the incidence of non-hepatic hyperammonemia and the prognosis of patients in the intensive care unit

Table 1 Linear relationship between blood ammonia and various indicators

	H-Ammonia		M-Ammonia		I-Ammonia
	r	P value	r	P value	r	P value
Age	-0.161	0.022	0.136	0.052	0.008	0.236
Days in ICU	0.314	0.000	0.004	0.572	0.004	0.573
APACH-II	0.240	0.000	0.221	0.002	0.263	0.000
H-SOFA	0.312	0.000	-	-	-	-
L-GCS	-0.205	0.004	-	-	-	-
M-SOFA	-	-	0.279	0.000	-	-
M-GCS	-	-	-0.183	0.009	-	-
I-SOFA	-	-	-	-	0.278	0.000
I-GCS	-	-	-	-	-0.174	0.013

P < 0.05 was considered statistically significant. M-Ammonia: Mean-level of ammonia; I-Ammonia: Initial-level of ammonia; ICU: Intensive care unit; APACHE-II: Acute Physiologic Assessment and Chronic Health Evaluation II; H-SOFA: The high level of Sequential Organ Failure Assessment score; L-GCS: The low level of Glasgow Coma Scale score; M-SOFA: The mean level of Sequential Organ Failure Assessment score; M-GCS: The mean level of Glasgow Coma Scale score; I-SOFA: The initial level of Sequential Organ Failure Assessment score; I-GCS: The initial level of Glasgow Coma Scale score.

Table 2 Comparison of prognosis between groups

Variables, mean ± SD	Good	Poor	t/Z	P value
Age (yr)	51.58 ± 18.49	52.51 ± 18.24	-0.434	0.665
Sex (M/F)	69/76	32/27	0.742	0.389
Time in ICU (d)	3.32 ± 2.57	3.53 ± 3.81	-0.999	0.318
APACHE-II	12.36 ± 7.53	20.39 ± 10.77	-4.933	0.000
H-Ammonia, μmol/L	67.06 ± 48.24	81.69 ± 59.63	-1.776	0.076
M-Ammonia, μmol/L	47.70 ± 23.79	63.85 ± 46.35	-2.039	0.041
I-Ammonia, μmol/L	48.43 ± 30.97	65.17 ± 46.26	-2.516	0.012

Good means cure or transferred to the ward; Poor means unhealed or died. P < 0.05 was considered statistically significant. ICU: Intensive care unit; APACHE-II: Acute Physiologic Assessment and Chronic Health Evaluation II; H-Ammonia: High-level of ammonia; I-Ammonia: Initial-level of ammonia.

Table 3 The logistic regression analysis of ammonia

	B	S.E.	Wald	P value	Exp (B)	95%CI for Exp (B)
						Lower	Upper
H-Ammonia	-0.0051	0.0028	3.2123	0.0731	0.9949	0.9894	1.0005
M-Ammonia	-0.0144	0.0049	8.6664	0.0032	0.9857	0.9762	0.9952
I-Ammonia	-0.0116	0.0041	7.8614	0.0051	0.9885	0.9805	0.9965

P < 0.05 was considered statistically significant. Exp: Expedition; H-Ammonia: High-level of ammonia; M-Ammonia: Mean-level of ammonia; I-Ammonia: Initial-level of ammonia.

Table 4 Comparison between drug poisoning and non-drug poisoning

Variables, mean ± SD	Drug poisoning n (20)	Non-drug poisoning n (184)	P value
H-Ammonia, μmol/L	86.70 ± 46.54	69.61 ± 52.47	0.032
M-Ammonia, μmol/L	68.11 ± 36.88	50.66 ± 31.85	0.016
I-Ammonia, μmol/L	73.10 ± 46.37	51.12 ± 35.01	0.024

P < 0.05 was considered statistically significant. H-Ammonia: High-level of ammonia; M-Ammonia: Mean-level of ammonia; I-Ammonia: Initial-level of ammonia.