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©The Author(s) 2020.
World J Gastroenterol. Dec 7, 2020; 26(45): 7173-7190
Published online Dec 7, 2020. doi: 10.3748/wjg.v26.i45.7173
Published online Dec 7, 2020. doi: 10.3748/wjg.v26.i45.7173
Table 1 Demographic and clinical information of participants included in the study
Feature | HCs (n = 38) | ADA patients (n = 33) | CRC patients (n = 46) | P value |
Age (yr) | 56.85 ± 10.99 | 61.18 ± 8.53 | 63.63 ± 11.39 | 0.095 |
Gender (male:female) | 24:14 | 23:10 | 32:14 | 0.799 |
BMI (kg/m2) | 23.86 ± 3.84 | 24.817 ± 3.31 | 23.66 ± 2.88 | 0.676 |
Smoking history (%) | 10 (26.3) | 15 (45.5) | 17 (37.0) | 0.241 |
Drinking history (%) | 14 (36.8) | 9 (27.3) | 12 (26.1) | 0.522 |
CRC of FDRs (%) | 6 (21.4) | 8 (24.2) | 8 (17.4) | 0.753 |
Table 2 Concentrations of tryptophan and tryptophan metabolites in patients and healthy controls
Metabolite (nmol/L) | Controls (n = 28) | ADA patients (n = 24) | CRC patients (n = 39) | Intergroup comparisons (P value) | ||
HC/ADA | HC/CRC | ADA/CRC | ||||
Trp | 196.67 (125.10, 353.30) | 289.46 (206.2, 393.72) | 241.88 (165.98, 429.16) | 0.081 | 0.118 | 0.611 |
KYN | 0.81 (0.64, 1.57) | 0.94 (0.66, 2.25) | 1.51 (0.70, 3.46) | 0.627 | 0.036 | 0.140 |
Indole | 252.00 (170.00, 545.00) | 251.00 (66.50, 366.75) | 356.00 (128.50, 729.25) | 0.213 | 0.878 | 0.170 |
Skatole | 210.00 (172.00, 223.00) | 137.00 (115.00, 206.00) | 231.00 (147.50, 265.50) | 0.111 | 0.495 | 0.019 |
IAA | 6.56 (1.25, 20.59) | 6.63 (3.35, 18.82) | 7.61 (1.85, 16.1) | 0.401 | 0.943 | 0.876 |
IPA | 10.67 (6.36, 15.48) | 7.75 (4.55, 10.38) | 7.65 (4.19, 13.11) | 0.025 | 0.025 | 0.348 |
IALD | 8.00 (4.25 15.50) | 19.50 (8.25, 31.75) | 37.00 (13.00, 63.00) | 0.044 | 0 | 0.024 |
I3CA | 1.13 (0.81, 1.71) | 1.10 (0.74, 2.11) | 3.64 (1.79, 8.15) | 0.971 | 0.011 | 0.028 |
Indoles | 428.24 (276.45, 963.95) | 325.50 (179.82, 504.33) | 547.87 (247.97, 823.64) | 0.100 | 0.955 | 0.044 |
Indoles/Trp ratio | 2.46 (1.25, 4.10) | 1.48 (0.58, 1.97) | 1.34 (0.70, 2.63) | 0.003 | 0.029 | 0.413 |
KYN/Trp ratio (× 10-3) | 5.23 (1.86, 7.99) | 3.73 (1.99, 11.39) | 7.39 (4.12, 11.72) | 0.845 | 0.032 | 0.105 |
- Citation: Sun XZ, Zhao DY, Zhou YC, Wang QQ, Qin G, Yao SK. Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer. World J Gastroenterol 2020; 26(45): 7173-7190
- URL: https://www.wjgnet.com/1007-9327/full/v26/i45/7173.htm
- DOI: https://dx.doi.org/10.3748/wjg.v26.i45.7173