Retrospective Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Oct 21, 2020; 26(39): 6047-6056
Published online Oct 21, 2020. doi: 10.3748/wjg.v26.i39.6047
Table 1 Clinicopathological findings according to the human papillomavirus positive or negative, n (%)

Total (n = 145)
HPV positive (n = 15)
HPV negative (n = 130)
P value
Sex
Male119 (82.1)12 (80.0)107 (82.3)0.73
Female26 (17.9)3 (20.0)23 (17.7)
Age (yr), mean ± SD66.3 ± 7.863.9 ± 9.366.6 ± 7.60.21
Tumor location
Cervical1 (0.7)1 (6.7)0 (0) 0.059
Upper22 (15.2)0 (0)22 (16.9)
Middle85 (58.6)11 (73.3)74 (56.9)
Lower36 (24.8)3 (20.0)33 (25.4)
Abdominal1 (0.7)0 (0)1 (0.8)
Main macroscopic type
0-Is1 (0.7)0 (0)1 (0.8)0.045
0-IIa16 (11.0)5 (33.3)11 (8.5)
0-IIb43 (29.7)4 (26.7)39 (30.0)
0-IIc85 (58.6)6 (40.0)79 (60.8)
Tumor size (mm), mean (SD)22.4 (10.6)26.5 (12.7)21.9 (10.3)0.11
Depth of invasion
EP53 (36.6)5 (33.3)48 (36.9)0.74
LPM66 (45.5)7 (46.7)59 (45.4)
MM19 (13.1)2 (13.3)17 (13.1)
SM14 (2.8)1 (6.7)3 (2.3)
SM23 (2.1)0 (0)3 (2.3)
Vascular invasion
Yes6 (4.1)2 (13.3)4 (3.1)0.12
No139 (95.9)13 (86.7)126 (96.9)
Table 2 Relationships of human papillomavirus status according to ISH with risk factors for esophageal squamous cell carcinoma, n (%)
HPVALDH2 genotype
P value
*1/*2 (n = 93)
*1/*1 + *2/*2 (n = 52)
Positive (n = 15)10 (10.8)5 (9.6)1.00
Negative (n = 130)83 (89.3)47 (90.4)
ADH1B genotype
*1/*1 (n = 25)*2 carrier (n = 120)
Positive (n = 15)3 (12.0)12 (10.0)0.72
Negative (n = 130)22 (88.0)108 (90.0)
Alcohol consumption
Light – Rare (n = 46)Heavy – Moderate (n = 99)
Positive (n = 15)4 (8.7)11 (11.1)0.68
Negative (n = 130)42 (91.3)88 (88.9)
Smoking habits
Light – Rare (n = 60)Heavy (n = 85)
Positive (n = 15)5 (8.3)10 (11.8)0.59
Negative (n = 130)55 (91.7)75 (88.2)
Genotype combinations
ABCDE
Positive (n = 15)0 (0.0)5 (10.9)3 (15.0)7 (9.6)0 (0.0)0.87
Negative (n = 130)5 (100.0)41 (89.1)17 (85.0)66 (90.4)1 (100.0)