Treatment of eosinophlic esophagitis with swallowed topical corticosteroids

Table 1 Overview of swallowed topical corticosteroids randomized trials in the treatment of eosinophilic esophagitis

Ref.	Patients (n)	Mean age	Topical steroid	Comparator	Formulation	Dosage/d	Duration (wk)	Histological remission Treatment/comparator (%)	Symptoms improved/above comparator
Konikoff et al[41] (2006)	36	9.6	Fluticasone	Placebo	Spray (swallowed)	2 × 440 μg	12	50/9	N/A
Schaefer et al[34] (2008)	80	7.2	Fluticasone	Prednisone	Spray (swallowed)	Fluticasone: 2 × 440-880 μg; Prednisone: 1 mg/kg/dose twice a day; maximum 30 mg twice a day	4	94/94	Yes/no
Peterson et al[40] (2010)	30	34.6	Fluticasone	Esomeprazole	Spray (swallowed)	Fluticasone: 2 × 440 μg; Esomeprazole: 1 × 40 mg	8	15 / 33	Yes/yes
Straumann et al[35] (2010)	36	36.0	Budesonide	Placebo	Suspension	2 × 1 mg	2	72/11	Yes/yes
Dohil et al[38] (2010)	32	7.8	Budesonide	Placebo	Suspension	1-2 mg body weight adapted	12	87/0	Yes/yes
Alexander et al[36] (2012)	42	37.5	Fluticasone	Placebo	Spray (swallowed)	2 × 880 μg	6	62/0	Yes/no
Dellon et al[42] (2012)	25	34.4	Budesonide	Budesonide (spray, swallowed)	Suspension	Suspension and spray: 2 × 1 mg	8	64/27	Yes/no
Moawad et al[39] (2013)	42	38.0	Fluticasone	Esomeprazole	Spray (swallowed)	Fluticasone: 2 × 440 μg; Esomeprazole: 1 × 40 mg	8	24 /18	No/no
Butz et al[43] (2014)	24	12.6	Fluticasone	Placebo	Spray (swallowed)	2 × 880 μg	12	65/0	No/no
Gupta et al[37] (2015)	81	9.1	Budesonide	Placebo	Suspension	0.35-2.8 mg age adapted	12	Low-dose: 24; Medium-dose: 53; High-dose: 94; Placebo: 6	Yes/no
Miehlke et al[45] (2016)	76	39.7	Budesonide	Placebo	Orodispersible tablet, suspension	Orodispersible tablet: 2 × 1 mg or 2 × 2 mg; Suspension: 2 × 2 mg	2	Orodispersible tablet: 100/95; Suspension: 95; Placebo: 0	Yes/no
Dellon et al[44] (2017)	93	21.5	Budesonide	Placebo	Suspension	2 × 2 mg	12	39/3	Yes/yes
Lucendo et al[50] (2019)	88	37.0	Budesonide	Placebo	Orodispersible tablet	2 × 1 mg	6	93/0	Yes/yes
Dellon et al[47] (2019)	129	36/39	Budesonide	Fluticasone	Budesonide: oral viscous; Fluticasone: spray (swallowed)	Budesonide: 2 × 1 mg; Fluticasone: 2 × 880 µg	8	71/64	Yes/no
1Hirano et al[49] (2017)	24	N/A	Fluticasone	Placebo	Orally disintegrating tablet	2 × 1.5 mg or 1 × 3 mg	8	N/A	Yes/yes
1Dellon et al[59] (2019)	103	N/A	Fluticasone	Placebo	Orally disintegrating tablet	2 × 3 mg or 1 × 3 mg or 2 × 1.5 mg or 1 × 1.5 mg	12	2 × 3 mg: 80; 1 × 3 mg: 66.7; 2 × 1.5 mg: 86.4; 1 × 1.5 mg: 47.6; Placebo: 0	Yes/N/A
1Hirano et al[48] (2019)	322	N/A	Budesonide	Placebo	Oral suspension	2 × 2 mg	12	53/1	Yes/yes

¹Abstract data. N/A: Not applicable.