Clinical features of cardiac nodularity-like appearance induced by Helicobacter pylori infection

Table 1 Characteristics of enrolled subjects

	H. pylori negative	H. pylori positive	H. pylori eradicated
Patient number	704	44	330
Mean age (standard deviation)	54.2 ± 11.1	51.0 ± 13.4	60.3 ± 12.3
Male:female	358:346	19:25	185:145
Cardiac nodularity	1 (0.14%)	24 (54.5%)a	15 (4.5%)bf
Antral nodularity	1 (0.14%)	13 (29.5%)	2 (0.6%)f

^aP < 0.05,

^bP < 0.01 vs antral nodularity;

^fP < 0.001 vs Helicobacter pylori positive. H. pylori: Helicobacter pylori.

Table 2 Clinical characteristics of cardiac nodularity in Helicobacter pylori positive patients

	Cardiac nodularity (+)	Cardiac nodularity (-)	P value
Patient number	24	20
Mean age (standard deviation)	44.9 ± 7.8	58.3 ± 15.1	0.0013
Male:female	9:15	10:10	0.598
Atrophy score	1.46 ± 0.59	1.55 ± 0.51	0.588
Intestinal metaplasia score	0.21 ± 0.59	0.80 ± 0.95	0.0216
Enlarged fold score	0.54 ± 0.51	0.60 ± 0.50	0.705
Diffuse redness score	1.75 ± 0.55	1.67 ± 0.64	0.648

Table 3 Clinical characteristics of cardiac nodularity in Helicobacter pylori eradicated patients

	Cardiac nodularity (+)	Cardiac nodularity (-)	P value
Patient number	15	315
Mean age (standard deviation)	49.2 ± 12.3	60.8 ± 12.1	0.0003
Male:female	5:10	180:135	0.121
Months after eradication	41.5 ± 30.1	91.6 ± 100.0	< 0.0001