Epigallocatechin gallate inhibits dimethylhydrazine-induced colorectal cancer in rats

Table 1 Average weight (g) of each group at different time points (mean ± SD)

Group	1 wk	6 wk	12 wk	20 wk
2	174.5 ± 6.2	188.8 ± 5.4	205.6 ± 4.5	216.1 ± 8.6
3	176.6 ± 4.8	186.1 ± 6.7	202.3 ± 4.3	221.7 ± 7.3
4	174.2 ± 5.7	185.7 ± 6.7	197.3 ± 10.6	218.4 ± 7.0
5	174.6 ± 5.2	175.7 ± 16.0b	194.8 ± 4.6a	211.8 ± 3.6

^aP < 0.05,

^bP < 0.01 vs Group 2.

Table 2 Aberrant crypt foci in different groups

Group	No. of rat		ACF
			Small intestine	P value	Colorectum		P value
1	10	0		-		0	-
2	10	5.0 ± 2.0		-		2.8 ± 0.9	-
3	18	4.9 ± 2.8		0.93		1.8 ± 1.0	0.03
4	19	3.9 ± 1.5		0.23		1.6 ± 0.5	0.01
5	20	3.9 ± 1.8		0.25		1.1 ± 0.3	< 0.01

Compared with Group 2. ACF: Aberrant crypt foci.

Table 3 Number and diameter of tumor in each group at 12^th and 20^th wk

Group	12 wk				20 wk
	Total	Non-cancerous	Cancerous	Diameter (mm3)	Total	Non-cancerous	Cancerous	Diameter (mm3)
1	0	0	0	0	0	0	0	0
2	11.75 ± 1.71	8.50 ± 1.29	3.25 ± 0.5	13.91 ± 1.89	21.40 ± 3.44	14.20 ± 2.49	7.20 ± 1.30	17.62 ± 2.21
3	9.50 ± 1.87	8.00 ± 1.55	1.5 ± 1.05	12.22 ± 1.67	17.08 ± 2.15b	12.67 ± 2.23	4.76 ± 0.87b	17.13 ± 1.66
4	8.38 ± 1.19b	7.25 ± 6.39	1.13 ± 0.84	10.92 ± 2.01a	13.36 ± 1.69b	10.08 ± 1.47b	2.91 ± 1.30b	13.60 ± 1.27a
5	7.80 ± 1.00bc	6.60 ± 1.14	0.4 ± 0.55a	6.04 ± 1.23bd	9.73 ± 2.34bd	8.40 ± 1.84bc	1.33 ± 0.90bc	8.15 ± 1.72bd

^aP < 0.05,

^bP < 0.01 vs Group 2.

^cP < 0.05,

^dP < 0.01 vs Group 3.