Pediatric living donor liver transplantation decade progress in Shanghai: Characteristics and risks factors of mortality

Table 1 Characteristics of the study population

Variable	Value
Recipient variables (n = 544)
Age (mo)	8.20 (7.00-13.95)
Weight (kg)	7.70 (6.80-9.20)
Male (%)	257 (47.24)
PELD score	17.00 (10.00-21.00)
Previous KP	216 (39.85%)
Donor variables (n = 544)
Donor age (yr)	31.00 (27.00-36.00)
Donor liver weight (g)	255.00 (225.00-290.00)
Donor liver cold ischemia time (min)	65.50 (56.00-77.00)

Data represent numbers (percentages) for categorical variables or median (interquartile ranges) for continuous variables. PELD: Pediatric end-stage liver disease; KP: Kasai procedure.

Table 2 Independent predictive factors of in-hospital patient survival

Independent predictive factor	Hospital death		P value
	Yes	No
Age (mo)
≤ 36	35	440	0.847
> 36	4	64
Gender
Male	19	238	0.857
Female	20	266
Weight (kg)
≤ 10	33	386	0.266
> 10	6	116
Diagnosis
Cholestatic cirrhosis	38	449	0.247
Metabolic disease	1	44
Others	0	11
Previous KP
No	25	301	0.611
Yes	14	201
PELD score
≤ 2	36	372	0.0321
> 2	3	118
Preoperative Hb (g/dL)
≤ 8	15	121	0.058
> 8	24	369
Anesthesia duration (min)
≤ 600	26	408	0.0271
> 600	13	94
Operation duration (min)
≤ 480	22	388	0.0031
> 480	17	114
Anhepatic phase (min)
≤ 40	22	227	0.145
> 40	16	270
Intraoperative blood loss (mL)
≤ 200	23	375	0.0451
> 200	15	123
GRWR (%)
2 ≤ x ≤ 4	28	348	0.593
< 2 or > 4	8	124
Cold ischemia time (min)
≤ 60	17	178	0.241
> 60	18	284
Perioperative RBC transfusion (U)
≤ 1	22	320	0.369
> 1	17	183
Perioperative blood transfusion (U)
Yes	39	466	0.099
No	0	38
Postoperative length of stay (d)
≤ 30	27	337	0.278
> 30	8	156
ICU MV duration (h)
≤ 24	20	370	0.199
> 24	6	60
ICU length of stay (d)
≤ 9	13	342	0.0001
> 9	15	95

¹Variables significantly associated with in-hospital patient survival (P < 0.05). PELD: Pediatric end-stage liver disease; KP: Kasai procedure; RBC: Red blood cell; Hb: Hemoglobin; GRWR: Graft to recipient weight ratio; ICU: Intensive care unit; MV: Mechanical ventilation.

Table 3 Multivariate analysis of one-year patient survival

Independent predictive factor	HR	95%CI	P value
ICU length of stay (d)
≤ 9	1
> 9	2.101	1.104-3.999	0.024
ICU MV duration (h)
≤ 8	1
> 8	2.230	1.159-4.290	0.016
PELD score
≤ 2	1
> 2	3.729	1.133-12.274	0.030
Preoperative Hb (g/dL)
≤ 8	1
> 8	0.637	0.327-1.239	0.184

HR: Hazard ratio; CI: Confidence interval; ICU: Intensive care unit; MV: Mechanical ventilation; PELD: Pediatric end-stage liver disease; Hb: Hemoglobin.

Table 4 Multivariate analysis of 3-year patient survival

Independent predictive factor	HR	95%CI	P value
ICU length of stay (d)
≤ 9	1
> 9	1.966	1.122-3.446	0.018
Length of surgery (h)
≤ 8	1
> 8	1.904	1.066-3.402	0.030
PELD
≤ 2	1
> 2	3.659	1.303-10.274	0.014

HR: Hazard ratio; CI: Confidence interval; ICU: Intensive care unit; PELD: Pediatric end-stage liver disease.