Copyright
©The Author(s) 2019.
World J Gastroenterol. Dec 21, 2019; 25(47): 6799-6812
Published online Dec 21, 2019. doi: 10.3748/wjg.v25.i47.6799
Published online Dec 21, 2019. doi: 10.3748/wjg.v25.i47.6799
Donor testing | Anti-HCV antibody | HCV RNA |
Donor terminology if positive | “Seropositive” | “NAT positive” or “Viremic” |
Acute infection | (-) | + |
Chronic infection | + | + |
Resolved | + | (-) |
Cyclosporine (CSA) | Tacrolimus (TAC) | Sirolimus (SRL) | Everolimus (EVR) | |
Sofosbuvir (SOF) | 4.5-fold ↑ in SOF AUC No dose adjustment necessary | 13% ↑ in SOF AUC No dose adjustment necessary | Not studied, no interaction expected No dose adjustment necessary | Not studied, no interaction expected No dose adjustment necessary |
Ledipasvir | Not studied, no interaction expected | Not studied, no interaction expected | Not studied, no interaction expected | Not studied, may increase EVR concentrations due to mild inhibition of P-gp by ledipasvir |
Paritaprevir / ritonavir / ombitasvir + dasabuvir (PrOD) | 5.8-fold ↑ in CSA AUC Modeling suggests using 1/5 of CSA dose during PrOD treatment Frequent monitoring necessary | 57-fold ↑ in TAC AUC Modeling suggests TAC 0.5 mg every 7 days during PrOD treatment | 38-fold ↑ in SRL AUC Do NOT co-administer | 27.1-fold ↑ in EVR AUC Do NOT co-administer |
Elbasvir / grazoprevir (EBR/GZR) | 15-fold ↑ in GZR AUC and 2-fold ↑ in EBR AUC Do NOT co-administer | 43% ↑ in TAC AUC No a priori dose adjustment necessary | Not studied, may increase SRL concentrations due to mild inhibition of P-gp by elbasvir | Not studied, may increase EVR concentrations due to mild inhibition of P-gp by elbasvir |
Velpatasvir | No interaction observed; no a priori dose adjustment necessary | No data; no a priori dose adjustment necessary | No data; no a priori dose adjustment necessary | Not studied, may increase EVR concentrations due to mild inhibition of P-gp by velpatasvir |
Glecaprevir / pibrentasvir (GLE/PIB) | 5-fold ↑ in GLE AUC with higher doses (400 mg) of CSA Not recommended in patients requiring stable CSA doses > 100 mg/day | 1.45-fold ↑ in TAC AUC No a priori dose adjustment, monitor TAC levels and titrate TAC dose as needed | Not studied, may increase SRL concentrations due to mild inhibition of P-gp by pibrentasvir | Not studied, may increase EVR concentrations due to mild inhibition of P-gp by pibrentasvir |
Sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) | 9.4-fold ↑ in VOX AUC Do NOT co-administer | No data; no a priori dose adjustment | Not studied, may increase SRL concentrations due to mild inhibition of P-gp by velpatasvir and voxilaprevir | Not studied, may increase EVR concentrations due to mild inhibition of P-gp by velpatasvir and voxilaprevir |
1-yr | 2-yr | |
DNAT-/R- | 93% | 88% |
DNAT-/R+ | 93% | 88% |
DNAT+/R- | 93% | 86% |
DNAT+/R+ | 94% | 90% |
- Citation: Crismale JF, Ahmad J. Expanding the donor pool: Hepatitis C, hepatitis B and human immunodeficiency virus-positive donors in liver transplantation. World J Gastroenterol 2019; 25(47): 6799-6812
- URL: https://www.wjgnet.com/1007-9327/full/v25/i47/6799.htm
- DOI: https://dx.doi.org/10.3748/wjg.v25.i47.6799