Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2019; 25(47): 6799-6812
Published online Dec 21, 2019. doi: 10.3748/wjg.v25.i47.6799
Expanding the donor pool: Hepatitis C, hepatitis B and human immunodeficiency virus-positive donors in liver transplantation
James F Crismale, Jawad Ahmad
James F Crismale, Jawad Ahmad, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Author contributions: Crismale JF and Ahmad J performed the literature review and wrote and edited portions of the final manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jawad Ahmad, FAASLD, FRCP (Hon), MD, Professor, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, United States.
Telephone: +1-212-2418035 Fax: +1-212-7317340
Received: August 12, 2019
Peer-review started: August 12, 2019
First decision: September 10, 2019
Revised: November 26, 2019
Accepted: November 29, 2019
Article in press: November 29, 2019
Published online: December 21, 2019
Core Tip

Core tip: The optimal utilization of organs from hepatitis C (HCV), hepatitis B (HBV) and human immunodeficiency virus (HIV)-positive donors may help attenuate the current organ shortage. Transplantation of organs from patients with HCV viremia to uninfected recipients can be accomplished safely when coupled with the timely initiation of post-transplant direct-acting antiviral therapy. Suppression of HBV with antiviral therapy allows for the safe transplantation from HBV core antibody-positive donors to unexposed recipients, while transplantation of organs from patients who are HBV surface antigen-positive remains investigational. The early experience with HIV-to-HIV positive transplantation via the HOPE act is promising, and allows patients living with HIV improved access to transplantation.