Minireviews
Copyright ©The Author(s) 2019.
World J Gastroenterol. Oct 28, 2019; 25(40): 6053-6062
Published online Oct 28, 2019. doi: 10.3748/wjg.v25.i40.6053
Table 1 Quantitative ultrasound: Optimal cutoffs obtained using proton density fat fraction with magnetic resonance imaging as the reference standard
TechniqueS0 vs S1–S3S0–S1 vs S2–S3S0–S2 vs S3
BSC[20], 1/cm-sr (NAFLD)0.0038------------------
Sensitivity: 93%------------------
Specificity: 97%------------------
CAP[30], dB/m (NAFLD)288------------------
Sensitivity: 75%
Specificity: 77%
ATI[40], dB/cm/MHz (NAFLD)0.630.72---------
Sensitivity: 80%Sensitivity: 100%---------
Specificity: 89%Specificity: 78%---------
UGAP[43], dB/cm/MHz (NAFLD)0.630.680.74
Sensitivity: 80%Sensitivity: 83%Sensitivity: 87%
Specificity: 91%Specificity: 74%Specificity: 79%
SSE[46], mm/μs (not specified)1.5371.511---------
Sensitivity: 80%Sensitivity: 100%---------
Specificity: 86%Specificity: 96%---------
In parenthesis: Etiology of liver disease. BSC: Backscatter coefficient; sr: Square radian; CAP: Controlled attenuation parameter; dB: Decibel; ATI: Attenuation imaging; MHz: Megahertz; UGAP: Ultrasound guided attenuation parameter; SSE: Sound speed estimation; NAFLD: Non-alcoholic fatty liver disease.
Table 2 Quantitative ultrasound: Optimal cutoffs obtained using liver biopsy as the reference standard
TechniqueS0 vs S1–S3S0–S1 vs S2–S3S0–S2 vs S3
CAP[24,25], dB/m (viral hepatitis)219-222233-296290
Sensitivity: 76-91%Sensitivity: 60-87%Sensitivity: 78%
Specificity: 52-71%Specificity: 74-91%Specificity: 93%
CAP[26-28], dB/m (mixed etiologies)255-266283-311293-318
Sensitivity: 65-75%Sensitivity: 57-86%Sensitivity: 83-88%
Specificity: 82-87%Specificity: 85-94%Specificity: 81-91%
CAP[29], dB/m1 (mixed etiologies)248268280
Sensitivity: 69%Sensitivity: 77%Sensitivity: 88%
Specificity: 82%Specificity: 81%Specificity: 78%
CAP[32], dB/m (NAFLD)302331337
Sensitivity: 80%Sensitivity: 70%Sensitivity: 72%
Specificity: 83%Specificity: 76%Specificity: 63%
ATI[41], dB/cm/MHz (mixed etiologies)0.630.700.74
Sensitivity: 74%Sensitivity: 86%Sensitivity: 100%
Specificity: 77%Specificity: 81%Specificity: 82%
UGAP[42], dB/cm/MHz (mixed etiologies)0.530.600.65
Sensitivity: 81%Sensitivity: 86%Sensitivity: 84%
Specificity: 87%Specificity: 81%Specificity: 90%
ATT[44], dB/cm/MHz (mixed etiologies)0.620.670.73
Sensitivity: 72%Sensitivity: 87%Sensitivity: 82%
Specificity: 82%Specificity: 72%Specificity: 89%
1Individual patient data meta-analysis. In parentheses: etiology of liver disease. CAP: Controlled attenuation parameter; dB: decibel; ATI: Attenuation imaging; MHz: Megahertz; UGAP: Ultrasound guided attenuation parameter; ATT: Attenuation.