Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure

doi:10.3748/wjg.v25.i37.5667

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Oct 7, 2019; 25(37): 5667-5675
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5667

Table 1 Demographic and clinical characteristics of the study subjects

Variable	HBV-ACLF (n = 43)	CHB (n = 43)	HCs (n = 20)
Age (yr)	42.65 ± 13.93	40.24 ± 14.41	41.00 ± 11.20
Male (%)	36 (83.7%)	35 (81.4%)	16 (80%)
ALB (g/L)	29.90 ± 4.45^a^b	36.62 ± 4.60	45.07 ± 2.31
TBIL (μmol/L)	351.92 ± 190.27^a^b	69.41 ± 95.43	8.00 ± 3.49
Cr (μmol/L)	95.56 ± 55.81^a^b	63.82 ± 11.97	65.00 ± 11.61
INR	2.01 (1.13)^a^b	1.13 (0.26)	0.95 (0.10)
HBeAg (positive rate, %)	14 (32.55%)	21 (48.84%)	ND
HBV-DNA (log₁₀ copies/mL)	6.74 ± 7.35^b	4.88 ± 1.99	ND
PCT (ng/mL)	0.53 (0.43)^a^b	0.07 (0.20)	0.02 (0.02)
IL-6 (pg/mL)	15.50 (24.00)^a^b	7.50 (7.00)	4.00 (4.00)
MELD	33.48 ± 4.79^b	8.43 ± 7.42	ND
sMR (pg/mL)	114.94 ± 49.65^a^b	80.75 ± 34.45	26.51 ± 8.62

The normally distributed data are expressed as the mean ± standard deviation. The non-normally distributed data are expressed as the median (interquartile range).

^aP < 0.05 vs HCs;

^bP < 0.05 vs CHB.

HBV: Hepatitis B virus; ACLF: Acute-on-chronic liver failure; CHB: Chronic hepatitis B; HCs: Healthy controls; ALB: Albumin; PTA: Prothrombin activity; TBIL: Total bilirubin; Cr: Creatinine; INR: International normalized ratio; HBeAg: Hepatitis B e antigen; PCT: Procalcitonin; IL-6: Interleukin-6; MELD: Model for end-stage liver disease; sMR: Soluble mannose receptor; ND: Not determined.

Table 2 Risk factors for 90-d mortality in patients with hepatitis B virus-related acute-on-chronic liver failure

Baseline variable	OR	Univariate 95%CI	P-value	OR	Multivariate 95%CI	P-value
Age (yr)	0.850	0.701–1.051	0.642
Gender	0.519	0.096–2.741	0.422
ALB (g/L)	0.722	0.567–1.052	0.102
PCT (ng/mL)	1.003	0.999–1.006	0.152
IL-6 (pg/mL)	1.022	1.005–1.038	0.187
MELD	1.422	1.038–2.693	0.001	1.132	1.046-1.396	0.001
sMR (pg/mL)	1.062	1.005–1.038	0.001	1.007	1.004-1.012	0.001

HBV: Hepatitis B virus; ACLF: Acute-on-chronic liver failure. OR: Odds ratio; CI: Confidence interval; ALB: Albumin; PCT: Procalcitonin; IL-6: Interleukin-6; MELD: Model for end-stage liver disease; sMR: Soluble mannose receptor.

Citation: Li TP, Guan SH, Wang Q, Chen LW, Yang K, Zhang H. Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure. World J Gastroenterol 2019; 25(37): 5667-5675
URL: https://www.wjgnet.com/1007-9327/full/v25/i37/5667.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i37.5667