Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2019; 25(37): 5667-5675
Published online Oct 7, 2019. doi: 10.3748/wjg.v25.i37.5667
Soluble mannose receptor as a predictor of prognosis of hepatitis B virus-related acute-on-chronic liver failure
Tai-Ping Li, Shi-He Guan, Qin Wang, Li-Wen Chen, Kai Yang, Hao Zhang
Tai-Ping Li, Shi-He Guan, Qin Wang, Li-Wen Chen, Kai Yang, Hao Zhang, Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China
Author contributions: Li TP acquired the data and drafted the manuscript; Li TP and Wang Q collected clinical samples and performed in vitro experiments; Li TP, Wang Q, and Chen LW analyzed the data; Yang K and Zhang H performed statistical analysis; Guan SH reviewed the manuscript, figures, and tables.
Supported by the Class A Project of the Key Research and Development Programs of the Science and Technology Department of Anhui Province, No. 1804h08020236; and the Key Project of the Natural Science Foundation of Anhui Province, No. KJ2018A0206.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Second Hospital of Anhui Medical University.
Informed consent statement: All study participants provided written informed consent prior to study enrolment.
Conflict-of-interest statement: There are no potential conflicts of interest relevant to this article to be reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Shi-He Guan, MD, PhD, Full Professor, Department of Clinical Laboratory, The Second Hospital of Anhui Medical University, Furong Road 678#, Hefei 230601, Anhui Province, China. shiheguan@126.com
Telephone: +86-551-63869508 Fax: +86-551-63869400
Received: July 15, 2019
Peer-review started: July 16, 2019
First decision: August 2, 2019
Revised: August 21, 2019
Accepted: September 11, 2019
Article in press: September 11, 2019
Published online: October 7, 2019
Processing time: 76 Days and 13.5 Hours
ARTICLE HIGHLIGHTS
Research background

Since hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a syndrome with a high short-term mortality rate, and clinically identifying those patients at a high mortality risk is of great significance.

Research motivation

The aim of this study was to investigate the clinical value of soluble mannose receptor (sMR) in patients with HBV-ACLF.

Research objectives

To investigate the clinical value of sMR for predicting 90-d mortality of patients with HBV-ACLF.

Research methods

A total of 43 patients with HBV-ACLF were enrolled in this retrospective study, and their serum sMR levels were determined using an enzyme-linked immunosorbent assay. A multivariate logistic regression analysis was used to analyze the independent risk factors for mortality.

Research results

When compared with chronic hepatitis B patients and healthy controls, serum sMR level was significantly higher in HBV-ACLF patients. Serum sMR helped to distinguish the survivors from non-survivors, and it was positively correlated with model for end-stage liver disease (MELD) score, HBV-DNA level, and total bilirubin level. In addition, serum sMR level was an independent risk factor and significantly improved the performance of MELD score in predicting the prognosis of HBV-ACLF patients.

Research conclusions

Serum sMR level is significantly elevated in patients with HBV-ACLF, and it is significantly associated with indicators of liver injury and disease severity. Additionally, sMR level is negatively correlated with patients outcome. Finally, sMR level may be a predictor of the prognosis of patients with HBV-ACLF.

Research perspectives

Future studies are needed to investigate the mechanisms underlying the role of sMR. And it is necessary to determine the dynamic changes in serum sMR during the progression of HBV-ACLF. Multicenter trials with large sample sizes are also required to confirm the current findings.